LncRNAs and the cancer epigenome: mechanisms and therapeutic potential

R Nadhan, C Isidoro, YS Song, DN Dhanasekaran - Cancer Letters, 2024 - Elsevier
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of epigenome,
modulating gene expression through DNA methylation, histone modification, and/or …

The roles and mechanisms of coding and noncoding RNA variations in cancer

SY Kim, MJ Na, S Yoon, E Shin, JW Ha… - … & Molecular Medicine, 2024 - nature.com
Functional variations in coding and noncoding RNAs are crucial in tumorigenesis, with
cancer-specific alterations often resulting from chemical modifications and …

Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease

A Caporali, M Anwar, Y Devaux, R Katare… - Nature Reviews …, 2024 - nature.com
The adult heart is a complex, multicellular organ that is subjected to a series of regulatory
stimuli and circuits and has poor reparative potential. Despite progress in our understanding …

Advancements in long non-coding RNA-based therapies for cancer: Targeting, delivery, and clinical implications

M Ammad, Z Javed, H Sadia, R Ahmed, A Akbar… - Medical Oncology, 2024 - Springer
Long non-coding RNAs (lncRNAs) have been in the spotlight for the past two decades due
to their extensive role in regulating a wide range of cellular processes. Development …

Sialylation-associated long non-coding RNA signature predicts the prognosis, tumor microenvironment, and immunotherapy and chemotherapy options in uterine …

J Chen, T Wu, Y Yang - Cancer Cell International, 2024 - Springer
Background Sialylation in uterine corpus endometrial carcinoma (UCEC) differs significantly
from apoptotic and ferroptosis pathways. It plays a crucial role in cancer progression and …

STAT6/LINC01637 axis regulates tumor growth via autophagy and pharmacological targeting STAT6 as a novel strategy for uveal melanoma

B Liu, X Yao, Q Huang, Y Fan, B Yu, J Wang… - Cell Death & …, 2024 - nature.com
Compelling evidence has revealed a novel function of the STAT pathway in the
pathophysiology of uveal melanoma (UM); however, its regulatory mechanisms remain …

Epigenetic modifications in solid tumor metastasis in people of African ancestry

EK Oladipo, SE Olufemi, DA Adediran… - Frontiers in …, 2024 - frontiersin.org
This review focuses on the critical role of epigenetic modifications in solid tumor metastasis,
particularly in people of African ancestry. Epigenetic alterations, such as DNA methylation …

Biobanks in chronic disease management: A comprehensive review of strategies, challenges, and future directions

W Xu, X Liang, L Chen, W Hong, X Hu - Heliyon, 2024 - cell.com
Biobanks, through the collection and storage of patient blood, tissue, genomic, and other
biological samples, provide unique and rich resources for the research and management of …

Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

ASA Altamimi, N Ghaboura, AK Balaraman… - … -Research and Practice, 2024 - Elsevier
Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a
novel form of regulated cell death known as disulfidptosis, characterized by accumulating …

Long non-coding RNAs: roles in cellular stress responses and epigenetic mechanisms regulating chromatin

JA Nickerson, F Momen-Heravi - Nucleus, 2024 - Taylor & Francis
Most of the genome is transcribed into RNA but only 2% of the sequence codes for proteins.
Non-coding RNA transcripts include a very large number of long noncoding RNAs …