Aloe vera is a kind of herb rich in polysaccharides. Acemannan (AC) is considered to be a
natural polysaccharide with good biodegradability and biocompatibility extracted from Aloe …

Despite major research efforts to elucidate mechanisms of non-union formation, failed
fracture healing remains a common complication in orthopedic surgery. Adequate …

Transplantation of mesenchymal stem cells (MSCs) has been considered an effective
therapeutic treatment for a variety of diseases including bone fracture. However, there are …

The objective of this study was to investigate the controlled release of two growth factors
(BMP-2 and VEGF) as a treatment strategy for bone healing in clinically challenging …

Collagen is the most abundant protein in mammals, accounting for approximately one-third
of the total protein in the human body. Thus, it is a logical choice for the creation of …

Successful bone healing in severe trauma depends on early revascularization to restore
oxygen, nutrient, growth factor, and progenitor cell supply to the injury. Therapeutic …

Bone nonunions arising from large bone defects and composite injuries remain compelling
challenges for orthopedic surgeons. Biological changes associated with nonunions, such as …

Bilateral communication between bones and muscles is essential for healing composite
bone–muscle injuries from orthopedic surgeries and trauma. However, these injuries are …

Adipose tissue-derived microvascular fragments (MVF) are functional vessel segments,
which rapidly reassemble into new microvasculatures under experimental in vitro and in vivo …

Background: Current therapies to effectively treat long-bone defects and extensive bone
tissue loss remains limited. In this study, we created a new bone substitute by integrating …