[HTML][HTML] Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review

Z Vinarov, M Abdallah, JAG Agundez… - European Journal of …, 2021 - Elsevier
The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Current sampling methods for gut microbiota: a call for more precise devices

Q Tang, G Jin, G Wang, T Liu, X Liu… - Frontiers in cellular and …, 2020 - frontiersin.org
The development of next-generation sequencing technology has enabled researchers to
explore and understand the gut microbiome from a broader and deeper perspective …

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

AP Singh, A Biswas, A Shukla, P Maiti - Signal transduction and …, 2019 - nature.com
The application of nanomedicines is increasing rapidly with the promise of targeted and
efficient drug delivery. Nanomedicines address the shortcomings of conventional therapy, as …

[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Advances in oral drug delivery systems: Challenges and opportunities

J Lou, H Duan, Q Qin, Z Teng, F Gan, X Zhou, X Zhou - Pharmaceutics, 2023 - mdpi.com
The oral route is the most preferred route for systemic and local drug delivery. However, the
oral drug delivery system faces the harsh physiological and physicochemical environment of …

Selenium in human health and gut microflora: bioavailability of selenocompounds and relationship with diseases

RLU Ferreira, KCM Sena-Evangelista… - Frontiers in …, 2021 - frontiersin.org
This review covers current knowledge of selenium in the dietary intake, its bioavailability,
metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship …

Corrosion and surface modification on biocompatible metals: A review

RIM Asri, WSW Harun, M Samykano, NAC Lah… - Materials Science and …, 2017 - Elsevier
Corrosion prevention in biomaterials has become crucial particularly to overcome
inflammation and allergic reactions caused by the biomaterials' implants towards the human …

Short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

PA Gill, MC Van Zelm, JG Muir… - Alimentary …, 2018 - Wiley Online Library
Background Butyrate, propionate and acetate are short chain fatty acids (SCFA), important
for maintaining a healthy colon and are considered as protective in colorectal …

[HTML][HTML] The mechanisms of pharmacokinetic food-drug interactions–A perspective from the UNGAP group

M Koziolek, S Alcaro, P Augustijns, AW Basit… - European Journal of …, 2019 - Elsevier
The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …

[HTML][HTML] Akkermansia muciniphila in the human gastrointestinal tract: when, where, and how?

SY Geerlings, I Kostopoulos, WM De Vos, C Belzer - Microorganisms, 2018 - mdpi.com
Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its
abundance in the human intestinal tract is inversely correlated to several disease states. A …