The ESCRT complexes
JH Hurley - Critical reviews in biochemistry and molecular biology, 2010 - Taylor & Francis
The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0,-I,-
II,-III, and Vps4–Vta1, and the ALIX homodimer. The ESCRT system is required for …
II,-III, and Vps4–Vta1, and the ALIX homodimer. The ESCRT system is required for …
The role of exosome and the ESCRT pathway on enveloped virus infection
Y Ju, H Bai, L Ren, L Zhang - International Journal of Molecular Sciences, 2021 - mdpi.com
The endosomal sorting complex required for transport (ESCRT) system consists of
peripheral membrane protein complexes ESCRT-0,-I,-II,-III VPS4-VTA1, and ALIX …
peripheral membrane protein complexes ESCRT-0,-I,-II,-III VPS4-VTA1, and ALIX …
Novel approaches to inhibiting HIV-1 replication
CS Adamson, EO Freed - Antiviral research, 2010 - Elsevier
Considerable success has been achieved in the treatment of HIV-1 infection, and more than
two-dozen antiretroviral drugs are available targeting several distinct steps in the viral …
two-dozen antiretroviral drugs are available targeting several distinct steps in the viral …
[HTML][HTML] Functional role of Alix in HIV-1 replication
K Fujii, UM Munshi, SD Ablan, DG Demirov… - Virology, 2009 - Elsevier
Retroviral Gag proteins encode small peptide motifs known as late domains that promote the
release of virions from infected cells by interacting directly with host cell factors. Three types …
release of virions from infected cells by interacting directly with host cell factors. Three types …
HIV type 1 Gag as a target for antiviral therapy
The Gag proteins of HIV-1 are central players in virus particle assembly, release, and
maturation, and also function in the establishment of a productive infection. Despite their …
maturation, and also function in the establishment of a productive infection. Despite their …
The effect of inositol hexakisphosphate on HIV-1 particle production and infectivity can be modulated by mutations that affect the stability of the immature Gag lattice
The assembly of an HIV-1 particle begins with the construction of a spherical lattice
composed of hexamer subunits of the Gag polyprotein. The cellular metabolite inositol …
composed of hexamer subunits of the Gag polyprotein. The cellular metabolite inositol …
Crystallographic and functional analysis of the ESCRT-I/HIV-1 Gag PTAP interaction
Budding of HIV-1 requires the binding of the PTAP late domain of the Gag p6 protein to the
UEV domain of the TSG101 subunit of ESCRT-I. The normal function of this motif in cells is …
UEV domain of the TSG101 subunit of ESCRT-I. The normal function of this motif in cells is …
Live-cell coimaging of the genomic RNAs and Gag proteins of two lentiviruses
I Kemler, A Meehan, EM Poeschla - Journal of virology, 2010 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) Gag and genomic RNA determinants
required for encapsidation are well established, but where and when encapsidation occurs …
required for encapsidation are well established, but where and when encapsidation occurs …
The molecular biology of feline immunodeficiency virus (FIV)
JC Kenyon, AML Lever - Viruses, 2011 - pmc.ncbi.nlm.nih.gov
Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-
like illness in domestic cats. It is highly prevalent in several endangered feline species. In …
like illness in domestic cats. It is highly prevalent in several endangered feline species. In …
Functional replacement of a retroviral late domain by ubiquitin fusion
Retroviral Gag polyprotein precursors are both necessary and sufficient for the assembly
and release of virus‐like particles (VLPs) from infected cells. It is well established that small …
and release of virus‐like particles (VLPs) from infected cells. It is well established that small …