Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …

Dysregulation of innate immune responses can result in chronic inflammatory conditions.
Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but …

Background Patients with lung adenocarcinoma (LUAD) may be more predisposed to
coronavirus disease 2019 (COVID-19) and have a poorer prognosis. Currently, there is still …

Epigenetic regulation plays a central role in the regulation of a number of cellular processes
such as proliferation, differentiation, cell cycle, and apoptosis. In particular, small molecule …

Mastitis is a common disease that hinders the development of dairy industry and animal
husbandry. It leads to the abuse of antibiotics and the emergence of super drug-resistant …

Macrophage migration inhibitory factor (MIF) functions as a critical cytokine regulating
inflammatory and immune responses. Extensive research has demonstrated its involvement …

Backgrounds: Postbiotics produced by gut microbiota have exhibited diverse
pharmacological activities. Valeric acid, a postbiotic material produced by gut microbiota …

Acute kidney injury (AKI) is a complex clinical syndrome with multiple etiologies and
pathogenesis, which lacks early biomarkers and targeted therapy. Recently, macrophage …

Background Inflammation is not only involved in the development and progression of cancer
but also affects the response to therapy. The aim of this study was to investigate the …