Sequestosome1 (p62/SQSTM 1) is a multidomain protein that interacts with the autophagy
machinery as a key adaptor of target cargo. It interacts with phagophores through the LC3 …

Neurodegenerative diseases, characterized by a progressive loss of brain function, affect
the lives of millions of individuals worldwide. The complexity of the brain poses a challenge …

Simple Summary Multiple myeloma is a cancer of immunoglobulin-secreting cells that
accumulate in the bone marrow. Mesenchymal stromal cells are important components of …

p62/Sequestosome‐1 (SQSTM1) is a selective autophagy receptor that recruits and delivers
intracellular substrates for bulk clearance through the autophagy lysosomal pathway …

Abstract p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which
interacts with various signaling proteins to regulate a variety of cellular functions. Growing …

Abstract Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the
transportation, degradation and destruction of various proteins that cooperates with …

FAM46C is a non-canonical poly (A) polymerase uniquely mutated in up to 20% of multiple
myeloma (MM) patients, implying a tissue-specific tumor suppressor function. Here, we …

Abstract p62 is an important multifunctional adaptor protein participating in autophagy and
many other activities. Many studies have revealed that p62 is highly expressed in multiple …

Multiple myeloma (MM) is the second-most-common hematologic malignancy and the most
frequent cancer to involve bone. MM bone disease (MMBD) has devastating consequences …

Along with tumor progression, the bone marrow microenvironment is skewed in multiple
myeloma (MM), which underlies the unique pathophysiology of MM and confers …