Human mitochondrial DNA: particularities and diseases

M Habbane, J Montoya, T Rhouda, Y Sbaoui… - Biomedicines, 2021 - mdpi.com
Mitochondria are the cell's power site, transforming energy into a form that the cell can
employ for necessary metabolic reactions. These organelles present their own DNA …

Mitochondrial Dysfunction in Systemic Lupus Erythematosus with a Focus on Lupus Nephritis

M Halfon, AT Tankeu, C Ribi - International Journal of Molecular Sciences, 2024 - mdpi.com
Systemic lupus erythematosus (SLE) is an autoimmune disease affecting mostly women of
child-bearing age. Immune dysfunction in SLE results from disrupted apoptosis which lead …

Validated removal of nuclear pseudogenes and sequencing artefacts from mitochondrial metabarcode data

C Andújar, TJ Creedy, P Arribas… - Molecular Ecology …, 2021 - Wiley Online Library
Metabarcoding of Metazoa using mitochondrial genes may be confounded by both the
accumulation of PCR and sequencing artefacts and the co‐amplification of nuclear …

A battle for transmission: the cooperative and selfish animal mitochondrial genomes

A Klucnika, H Ma - Open biology, 2019 - royalsocietypublishing.org
The mitochondrial genome is an evolutionarily persistent and cooperative component of
metazoan cells that contributes to energy production and many other cellular processes …

A naturally heteroplasmic clam provides clues about the effects of genetic bottleneck on paternal mtDNA

M Iannello, S Bettinazzi, S Breton… - Genome biology and …, 2021 - academic.oup.com
Mitochondrial DNA (mtDNA) is present in multiple copies within an organism. Since these
copies are not identical, a single individual carries a heterogeneous population of mtDNAs …

Admixture and ancestry inference from ancient and modern samples through measures of population genetic drift

AM Harris, M DeGiorgio - Human Biology, 2017 - BioOne
Methods that leverage the information about population history contained within the
increasingly abundant genetic sequences of extant and extinct hominid populations are …

Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the free radical theory of ageing

D Jebb, NM Foley, CV Whelan, F Touzalin… - Scientific reports, 2018 - nature.com
Bats are the only mammals capable of true, powered flight, which drives an extremely high
metabolic rate. The “Free Radical Theory of Ageing”(FTRA) posits that a high metabolic rate …

Long-chain acyl coenzyme A dehydrogenase, a key player in metabolic rewiring/invasiveness in experimental tumors and human mesothelioma cell lines

DL Pouliquen, G Ortone, L Rumiano, A Boissard… - Cancers, 2023 - mdpi.com
Simple Summary This study aims to investigate mitochondrial metabolic differences
between invasive and non-invasive malignant mesotheliomas in order to find new …

Evolving mtDNA populations within cells

IG Johnston, JP Burgstaller - Biochemical Society Transactions, 2019 - portlandpress.com
Mitochondrial DNA (mtDNA) encodes vital respiratory machinery. Populations of mtDNA
molecules exist in most eukaryotic cells, subject to replication, degradation, mutation, and …

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel

RPJ Bevers, M Litovchenko, A Kapopoulou… - Nature …, 2019 - nature.com
The nature and extent of mitochondrial DNA variation in a population and how it affects traits
is poorly understood. Here we resequence the mitochondrial genomes of 169 Drosophila …