Caloric restriction mimetics in nutrition and clinical trials

SJ Hofer, S Davinelli, M Bergmann, G Scapagnini… - Frontiers in …, 2021 - frontiersin.org
The human diet and dietary patterns are closely linked to the health status. High-calorie
Western-style diets have increasingly come under scrutiny as their caloric load and …

D-allulose, a versatile rare sugar: recent biotechnological advances and challenges

W Zhang, D Chen, J Chen, W Xu, Q Chen… - Critical Reviews in …, 2023 - Taylor & Francis
D-Allulose is the C-3 epimer of D-fructose, and widely regarded as a promising substitute for
sucrose. It's an excellent low-calorie sweetener, with 70% sweetness of sucrose, 0.4 kcal/g …

[HTML][HTML] Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

MS Denzel, LR Lapierre, HID Mack - Mechanisms of ageing and …, 2019 - Elsevier
Key discoveries in aging research have been made possible with the use of model
organisms. Caenorhabditis elegans is a short-lived nematode that has become a well …

Calorie restriction mimetics: upstream-type compounds for modulating glucose metabolism

H Shintani, T Shintani, H Ashida, M Sato - Nutrients, 2018 - mdpi.com
Calorie restriction (CR) can prolong the human lifespan, but enforcing long-term CR is
difficult. Therefore, a compound that reproduces the effect of CR without CR is needed. In …

Recent advances regarding the physiological functions and biosynthesis of D-allulose

Z Chen, XD Gao, Z Li - Frontiers in Microbiology, 2022 - frontiersin.org
D-Allulose, a generally regarded as safe (GRAS) sugar, is rare in nature. It is among the
most promising sweeteners for future use due to its low caloric content, sucrose-like taste …

Allulose for the attenuation of postprandial blood glucose levels in healthy humans: A systematic review and meta-analysis

T Yuma, M Tokuda, N Nishimoto, H Yokoi, K Izumori - PLoS One, 2023 - journals.plos.org
D-Allulose is a rare sugar that exists in nature. It is a food ingredient with nearly zero calories
(< 0.4 kcal/g) and has many physiological functionalities such as attenuation of postprandial …

Research Advances of d-allulose: An Overview of Physiological Functions, Enzymatic Biotransformation Technologies, and Production Processes

Y Xia, Q Cheng, W Mu, X Hu, Z Sun, Y Qiu, X Liu… - Foods, 2021 - mdpi.com
d-allulose has a significant application value as a sugar substitute, not only as a food
ingredient and dietary supplement, but also with various physiological functions, such as …

Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics

DK Ingram, GS Roth - Geroscience, 2021 - Springer
Calorie restriction mimetics encompass a growing research field directed toward developing
treatments that mimic the anti-aging effects of long-term calorie restriction without requiring a …

The rare sugar d-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical

S Mochizuki, T Fukumoto, T Ohara, K Ohtani… - Communications …, 2020 - nature.com
The rare sugar d-tagatose is a safe natural product used as a commercial food ingredient.
Here, we show that d-tagatose controls a wide range of plant diseases and focus on downy …

Secoisolariciresinol Diglucoside Delays the Progression of Aging‐Related Diseases and Extends the Lifespan of Caenorhabditis elegans via DAF‐16 and HSF‐1

M Lu, L Tan, XG Zhou, ZL Yang, Q Zhu… - Oxidative medicine …, 2020 - Wiley Online Library
Secoisolariciresinol diglucoside (SDG) is a phytoestrogen and rich in food flaxseed,
sunflower seeds, and sesame seeds. Among the beneficial pharmacological activities of …