Improvements in the biological production of 1, 3-propanediol, a key component of an
emerging polymer business, have been realized. Utilizing genes from natural strains that …

Natural products account for more than 50% of all small-molecule pharmaceutical agents
currently in clinical use. However, low availability often becomes problematic when a …

Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in
Nature. Major progress has been made over the past decade in understanding how this …

Bacterial microcompartments (BMCs) are proteinaceous organelles involved in both
autotrophic and heterotrophic metabolism. All BMCs share homologous shell proteins but …

Using comparative analysis of genes, operons, and regulatory elements, we describe the
cobalamin (vitamin B 12) biosynthetic pathway in available prokaryotic genomes. Here we …

Bacterial microcompartments (MCPs) are sophisticated protein-based organelles used to
optimize metabolic pathways. They consist of metabolic enzymes encapsulated within a …

Hundreds of bacterial species produce proteinaceous microcompartments (MCPs) that act
as simple organelles by confining the enzymes of metabolic pathways that have toxic or …

Bacterial microcompartments (BMCs) are protein-bound organelles predicted to be present
across 23 bacterial phyla. BMCs facilitate carbon fixation as well as the aerobic and …

Cobalamin (B12) typically functions as an enzyme cofactor but can also regulate gene
expression via RNA-based riboswitches. B12-directed gene regulatory mechanisms via …

ABSTRACT Salmonella enterica grows on 1, 2-propanediol (1, 2-PD) in a coenzyme B12-
dependent fashion. Prior studies showed that a bacterial microcompartment (MCP) is …