Publisher Summary This chapter summarizes the experimental information on protein
energetics. This field is developing fast and the concept of the energetics of protein structure …

AUosteric proteins control and coordinate chemical events in the living cell. When Monod
conceived that idea he said that he had discovered the second secret of life. The first was …

The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene
expression. The crystal structure of a complex containing the three zinc fingers from Zif268 …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

We have determined the domains of the mammalian high mobility group (HMG) I
chromosomal proteins necessary and sufficient for binding to the narrow minor groove of …

Determinants of bacterial tetracycline resistance are located in transposons and R-factors.
They are encoded by the genes tetA and tetR and the products TetA, is tetracyline-proton …

Allostery is essential for controlled catalysis, signal transmission, receptor trafficking, turning
genes on and off, and apoptosis. It governs the organism's response to environmental and …

Strand-symmetric relative abundance functionals for di-, tri-, and tetranucleotides are
introduced and applied to sequences encompassing a broad phylogenetic range to discern …

Three regions of sequence similarity have been reported in several protein and small-
molecule S-adenosylmethionine-dependent methyltransferases. Using multiple alignments …

We compare and contrast genome-wide compositional biases and distributions of short
oligonucleotides across 15 diverse prokaryotes that have substantial genomic sequence …