Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Biology has taught us that a protein as abundantly made and conserved among species as
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …

Rationale & Objective Identification of novel risk factors for chronic kidney disease (CKD)
progression may inform mechanistic investigations and improve identification of high-risk …

A host of novel renal biomarkers have been developed over the past few decades which
have enhanced monitoring of renal disease and drug-induced kidney injury in both …

Chronic kidney disease is currently assessed by estimated glomerular filtration rate, a
mathematical construct based on creatinine or creatinine and cystatin concentration …

High serum concentrations of kidney-derived protein uromodulin [Tamm-Horsfall protein
(THP)] have recently been shown to be independently associated with low mortality in both …

Uromodulin (also known as Tamm–Horsfall protein) is a kidney-specific glycoprotein
secreted bidirectionally into urine and into the circulation, and it is the most abundant protein …

Aims Uromodulin is produced exclusively in the kidney and secreted into both urine and
blood. Serum levels of uromodulin are correlated with kidney function and reduced in …

Uromodulin, also known as Tamm-Horsfall protein, represents the predominant urinary
protein in healthy individuals. Over the years, studies have revealed compelling …

Background Uromodulin is specifically synthesized and secreted by kidney tubular epithelial
cells. Studies on the association of serum uromodulin and outcomes of chronic kidney …