Antibiotics effective against Gram‐negative ESKAPE pathogens are a critical area of unmet
need. Infections caused by these pathogens are not only difficult to treat but finding new …

At present, antibiotic resistance represents a global problem in modern medicine. In the near
future, humanity may face a situation where medicine will be powerless against resistant …

Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …

Antibiotic efflux is a mechanism that is well-documented in the phenotype of multidrug
resistance in bacteria. Efflux is considered as an early facilitating mechanism in the bacterial …

Highlights•RND pumps of P. aeruginosa and A. baumannii, fall into three different
categories.•The three categories of efflux pumps participate in different physiological …

Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

The clinical success of linezolid for treating Gram-positive infections paired with the high
conservation of bacterial ribosomes predicts that if oxazolidinones were engineered to …

Several factors affect the passive membrane permeation of small molecules, including size,
charge, pH, or the presence of specific chemical groups. Understanding these features is …

Two membrane cell envelopes act as selective permeability barriers in Gram-negative
bacteria, protecting cells against antibiotics and other small molecules. Significant efforts are …

Sensing of antibiotic–bacteria interactions is an important area of research that has gained
significant attention in recent years. Antibiotic resistance is a major public health concern …