Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites

J Cao, D Huang, NA Peppas - Advanced drug delivery reviews, 2020 - Elsevier
The widespread development of nanocarriers to deliver chemotherapeutics to specific tumor
sites has been motivated by the lack of selective targeting during chemotherapy inducing …

Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy

M Beygi, F Oroojalian, SS Hosseini… - Progress in Materials …, 2023 - Elsevier
The majority of advances in cancer therapy have been achieved based on developments in
public awareness, as well as novel diagnostic and therapeutic modalities. Treatment …

Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration

SM Kong, DF Costa, A Jagielska… - Proceedings of the …, 2021 - National Acad Sciences
Nanoparticle (NP) stiffness has been shown to significantly impact circulation time and
biodistribution in anticancer drug delivery. In particular, the relationship between particle …

In vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors

AB Mirkasymov, IV Zelepukin, PI Nikitin… - Journal of Controlled …, 2021 - Elsevier
Smart nanomaterials, contrast nanoparticles and drug nanocarriers of advanced targeting
architecture were designed for various biomedical applications. Most of such agents …

Emerging era of “somes”: Polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

AK Sharma, P Prasher, AA Aljabali, V Mishra… - Drug delivery and …, 2020 - Springer
Over the past two decades, polymersomes have been widely investigated for the delivery of
diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric …

Polymers and polymer nanocomposites for cancer therapy

D Feldman - Applied Sciences, 2019 - mdpi.com
Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of
them are already used in different medical areas. Among the synthetic ones that can be …

The in vivo fate of 225Ac daughter nuclides using polymersomes as a model carrier

RM Kruijff, R Raavé, A Kip, J Molkenboer-Kuenen… - Scientific reports, 2019 - nature.com
Increasing attention is given to personalized tumour therapy, where α-emitters can
potentially play an important role. Alpha particles are ideal for localized cell killing because …

[HTML][HTML] Polymersomes as a potential platform for cancer immunotherapy

JF Scheerstra, AC Wauters, J Tel… - Materials Today …, 2022 - Elsevier
With the focus in the field of cancer nanomedicine shifting from direct tumor targeting to
modulation of the immune system, new opportunities arise for the employment of …

Lymphatic transport system to circumvent hepatic metabolism for oral delivery of lipid-based nanocarriers

A Rajput, P Pingale, D Telange, S Chalikwar… - Journal of Drug Delivery …, 2021 - Elsevier
The oral route of administration for lipid-based nanocarriers is of immense importance for
the drugs having low bioavailability because of extensive first-pass metabolism. These drug …

Differences in human plasma protein interactions between various polymersomes and stealth liposomes as observed by fluorescence correlation spectroscopy

A Najer, O Rifaie‐Graham, J Yeow… - Macromolecular …, 2023 - Wiley Online Library
A significant factor hindering the clinical translation of polymersomes as vesicular
nanocarriers is the limited availability of comparative studies detailing their interaction with …