GABA receptor mechanisms in the central nervous system

L Sivilotti, A Nistri - Progress in neurobiology, 1991 - Elsevier
C1 equilibrium potential 1PSP reversal potential Dose producing a half-maximal response
Excitatory postsynaptic potential y-Aminobutyric acid GABA transaminase Glutamic acid …

Receptors for the age of anxiety: pharmacology of the benzodiazepines

JF Tallman, SM Paul, P Skolnick, DW Gallager - Science, 1980 - science.org
Investigation of the actions of the benzodiazepines has provided insights into the
neurochemical mechanisms underlying anxiety, seizures, muscle relaxation, and sedation …

Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors

AC Foster, GE Fagg - Brain Research Reviews, 1984 - Elsevier
This review summarizes studies designed to label and characterize mammalian synaptic
receptors for glutamate, aspartate and related acidic amino acids using in vitro ligand …

Drug and neurotransmitter receptors in the brain

SH Snyder - Science, 1984 - science.org
Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been
one of the most active areas of molecular neuroscience during the past decade. This work …

The GABA postsynaptic membrane receptor-ionophore complex: Site of action of convulsant and anticonvulsant drugs

RW Olsen - Molecular and cellular biochemistry, 1981 - Springer
The function of the inhibitory neurotransmitter, γ-aminobutyric acid (GABA), has been
implicated in the mode of action of many drugs which excite or depress the central nervous …

Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality

M Herkenham, CB Pert - Journal of Neuroscience, 1982 - Soc Neuroscience
A general technique is described for using slide-mounted unfixed tissue sections to
characterize and visualize drug and neurotransmitter receptors in brain or other tissues. The …

Noise raises blood pressure without impairing auditory sensitivity

EA Peterson, JS Augenstein, DC Tanis, DG Augenstein - Science, 1981 - science.org
Two rhesus monkeys, exposed continuously to realistic patterns and levels of noise for 9
months, exhibited sustained elevations in blood pressure that did not return to baseline …

Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors

CA Klepner, AS Lippa, DI Benson, MC Sano… - Pharmacology …, 1979 - Elsevier
Brain-specific binding sites have been isolated on synaptosomal membrane fragments
which recognize pharmacologically active benzodiazepine (BDZ's) and triazolopyridazines …

Agonist and antagonist benzodiazepine receptor interaction in vitro

H Möhler, JG Richards - Nature, 1981 - nature.com
A representative of a novel series of imidazodiazepines, Ro 15-1788, selectively
antagonizes all major central actions of benzodiazepines by competitive, high-affinity …

Benzodiazepine receptor ligands with positive and negative efficacy

C Braestrup, M Nielsen, T Honore, LH Jensen… - …, 1983 - Elsevier
Recent studies have shown that benzodiazepine receptors can be affected not only by
benzodiazepine agonists and antagonists but also by a new class of ligands which produce …