Ischemic stroke leads to high disability and mortality. The limited delivery efficiency of most
therapeutic substances is a major challenge for effective treatment of ischemic stroke …

Ischemic stroke is a vascular central nervous system (CNS) disease that leads a disability
and death. Thrombolysis and neuroprotection are the primary treatment strategies of …

Stroke is a primary cause of death and disability worldwide, while effective and safe drugs
remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle …

Microglial polarization is one of the most promising therapeutic strategies for multiple central
nervous system (CNS) disorders. However, safe, effective, and controllable microglial …

Ischemic stroke is an acute and serious cerebral vascular disease, which greatly affects
people's health and brings huge economic burden to society. Microglia, as important innate …

Rational design of nanomedicine to accelerate thrombolysis and sequentially avoid
thrombolysis-mediated reperfusion injury is still a challenge. Here, we develop a biomimetic …

In acute ischemic stroke therapy, potent neuroprotective agents are needed that prevent
neural injuries caused by reactive oxygen species (ROS) during ischemic reperfusion …

Inflammation plays an important role in the development of rheumatoid arthritis (RA). NR4A1
is an anti-inflammatory orphan nuclear receptor involved in protection from inflammatory …

Vascular disorders, characterized by vascular endothelial dysfunction combined with
inflammation, are correlated with numerous fatal diseases, such as coronavirus disease-19 …

Ischemic stroke (IS) represents a significant threat to brain health due to its elevated
mortality and disability rates. The efficacy of small-molecule neuroprotective agents has …