Metabolism of amino acids in cancer
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
Membrane protein stabilization strategies for structural and functional studies
E Errasti-Murugarren, P Bartoccioni, M Palacín - Membranes, 2021 - mdpi.com
Accounting for nearly two-thirds of known druggable targets, membrane proteins are highly
relevant for cell physiology and pharmacology. In this regard, the structural determination of …
relevant for cell physiology and pharmacology. In this regard, the structural determination of …
TMBIM5 is the Ca2+/H+ antiporter of mammalian mitochondria
Mitochondrial Ca2+ ions are crucial regulators of bioenergetics and cell death pathways.
Mitochondrial Ca2+ content and cytosolic Ca2+ homeostasis strictly depend on Ca2+ …
Mitochondrial Ca2+ content and cytosolic Ca2+ homeostasis strictly depend on Ca2+ …
Structural basis for substrate specificity of heteromeric transporters of neutral amino acids
CF Rodriguez, P Escudero-Bravo… - Proceedings of the …, 2021 - National Acad Sciences
Despite having similar structures, each member of the heteromeric amino acid transporter
(HAT) family shows exquisite preference for the exchange of certain amino acids. Substrate …
(HAT) family shows exquisite preference for the exchange of certain amino acids. Substrate …
[HTML][HTML] Lysine 204 is crucial for the antiport function of the human LAT1 transporter
Abstract LAT1 (SLC7A5) catalyzes an antiport reaction of amino acids with specificity
towards the essential ones. It is mainly expressed at the Blood Brain Barrier and placenta …
towards the essential ones. It is mainly expressed at the Blood Brain Barrier and placenta …
Insights into the Transport Cycle of LAT1 and Interaction with the Inhibitor JPH203
C Brunocilla, L Console, F Rovella… - International Journal of …, 2023 - mdpi.com
The large Amino Acid Transporter 1 (LAT1) is an interesting target in drug discovery since
this transporter is overexpressed in several human cancers. Furthermore, due to its location …
this transporter is overexpressed in several human cancers. Furthermore, due to its location …
LAT1 (SLC7A5) catalyzes copper (histidinate) transport switching from antiport to uniport mechanism
Summary LAT1 (SLC7A5) is one of the most studied membrane transporters due to its
relevance to physiology in supplying essential amino acids to brain and fetus, and to …
relevance to physiology in supplying essential amino acids to brain and fetus, and to …
Amino acid transporter LAT1 (SLC7A5) mediates MeHg-induced oxidative stress defense in the human placental cell line HTR-8/SVneo
S Granitzer, R Widhalm, M Forsthuber… - International journal of …, 2021 - mdpi.com
The placental barrier can protect the fetus from contact with harmful substances. The potent
neurotoxin methylmercury (MeHg), however, is very efficiently transported across the …
neurotoxin methylmercury (MeHg), however, is very efficiently transported across the …
LAT1, a novel pharmacological target for the treatment of glioblastoma
N Cappoli, MD Jenkinson, CD Russo… - Biochemical …, 2022 - Elsevier
Abstract The L-Type Amino Acid transporter, LAT1 (SLC7A5), has a crucial role in mediating
amino acid uptake into the cells, thus modulating cell growth and proliferation as well as …
amino acid uptake into the cells, thus modulating cell growth and proliferation as well as …
Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules
ESM Schleker, S Buschmann, H Xie… - Proceedings of the …, 2022 - National Acad Sciences
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are multidomain
transmembrane proteins, which facilitate the transport of various substances across cell …
transmembrane proteins, which facilitate the transport of various substances across cell …