Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …

To improve the understanding of chemo-refractory high-grade serous ovarian cancers
(HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) …

Abstract Background Patient-derived organoids (PDOs) from advanced colorectal cancer
(CRC) patients could be a key platform to predict drug response and discover new …

Anoikis resistance was a prominent hallmark of cancer metastasis, and lipo-genic
characteristics have been identified as another metabolic alteration during tumorigenesis …

Natural killer (NK) cells are a vital part of the innate immune system capable of rapidly
clearing mutated or infected cells from the body and promoting an immune response. Here …

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive OC
histotype. Although initially sensitive to standard platinum-based chemotherapy, most …

Lipids are a class of complex hydrophobic molecules derived from fatty acids that not only
form the structural basis of biological membranes but also regulate metabolism and maintain …

Ovarian cancer continues to have a high mortality rate despite therapeutic advances.
Traditionally, treatment has focused on surgery followed by systemic platinum-based …

Simple Summary The DNA damage response (DDR) is frequently altered in ovarian cancer
(OC), which can be exploited for therapeutic purposes. Moreover, targeting DDR signaling …