Progress and prospects toward supramolecular bioactive ion transporters
The majority of cellular physiological processes depend on natural ion channels, which are
pore-forming membrane-embedded proteins that let ions flow across the cell membranes …
pore-forming membrane-embedded proteins that let ions flow across the cell membranes …
A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy
Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion
transporters, have been known to induce cytotoxicity in cells by disrupting ionic …
transporters, have been known to induce cytotoxicity in cells by disrupting ionic …
New insights and discoveries in anion receptor chemistry
This review offers a broad overview of the advancements in anion receptor chemistry in
2021 and 2022. Detailed examples of acclaimed work in fundamental recognition, sensing …
2021 and 2022. Detailed examples of acclaimed work in fundamental recognition, sensing …
Non‐Covalently Stapled H+/Cl− Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy
Q Zhong, Y Cao, X Xie, Y Wu, Z Chen… - Angewandte …, 2024 - Wiley Online Library
The development of stimuli‐responsive artificial H+/Cl− ion channels, capable of specifically
disturbing the intracellular ion homeostasis of cancer cells, presents an intriguing …
disturbing the intracellular ion homeostasis of cancer cells, presents an intriguing …
Photocontrolled activation of doubly o-nitrobenzyl-protected small molecule benzimidazoles leads to cancer cell death
Artificial biomimetic chloride anionophores have shown promising applications as
anticancer scaffolds. Importantly, stimuli-responsive chloride transporters that can be …
anticancer scaffolds. Importantly, stimuli-responsive chloride transporters that can be …
[HTML][HTML] Tuning pH-dependent cytotoxicity in cancer cells by peripheral fluorine substitution on pseudopeptidic cages
The acidic microenvironment of solid tumors is a potential source of selectivity in the anti-
cancer activity of ionophores, which requires delicate control of their biophysical properties …
cancer activity of ionophores, which requires delicate control of their biophysical properties …
Tetralactam-based anion transporters
AM Gilchrist, DA McNaughton, M Fares, X Wu… - Chem, 2024 - cell.com
Synthetic anion transporters provide a promising avenue to treat diseases such as cystic
fibrosis and cancer. Anion binding site preorganization is one aspect of transporter design …
fibrosis and cancer. Anion binding site preorganization is one aspect of transporter design …
Platinum-based metal complexes as chloride transporters that trigger apoptosis
In this paper we demonstrate that Pt (II) complexes can function as efficient transmembrane
chloride transporters. A series of Pt (II) metal complexes with urea-appended isoquinoline …
chloride transporters. A series of Pt (II) metal complexes with urea-appended isoquinoline …
Small molecule-derived pH-gated ion transporters
N Kumar, N Madhavan - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
The pH regulation of transmembrane ion transport is critical for biological processes and has
a direct implication on diseases such as cancer. Synthetic transporters that can be regulated …
a direct implication on diseases such as cancer. Synthetic transporters that can be regulated …
Pyridyl-Linked Hetero Hydrazones: Transmembrane H+/Cl– Symporters with Efficient Antibacterial Activity
The development of potent antibacterial agents has become increasingly difficult as bacteria
continue to evolve and develop resistance to antibiotics. It is therefore imperative to find …
continue to evolve and develop resistance to antibiotics. It is therefore imperative to find …