Drug resistance is a major problem in cancer treatment, as it limits the effectiveness of
pharmacological agents and can lead to disease progression. Cold atmospheric plasma …

Simple Summary The extracellular matrix has a complex structure, and the glycans within
are difficult to study, but are able to elicit multiple effects on resident and immune cells, with …

Identifying metabolic steps that are specifically required for the survival of cancer cells but
are dispensable in normal cells remains a challenge. Here we report a therapeutic …

Highly sensitive and reproducible analysis of samples containing low amounts of protein is
restricted by sample loss and the introduction of contaminants during processing. Here, we …

In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of
each patient and reduce the toxicity caused by conventional antitumor strategies. It has been …

Hyaluronan (HA) is a ubiquitous extracellular matrix component playing a crucial role in the
regulation of cell behaviors, including cancer. Aggressive breast cancer cells tend to …

Therapy-induced senescence (TIS) is a state of stable proliferative arrest of both normal and
neoplastic cells that is triggered by exposure to anticancer treatments. TIS cells acquire a …

Abstract UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that
converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and …

Simple Summary Breast cancer is the most common neoplasm in women. Although the
primary tumor does not appear in a vital organ, lethality is due to the ability of tumor cells to …

Hyaluronan (HA) has gained significant attention in cancer research for its role in
modulating chemoresistance. This review aims to elucidate the mechanisms by which HA …