Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
Alzheimer's disease (AD) is a neurological, progressive illness that typically affects the
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
Novel oxadiazole-thiadiazole derivatives: synthesis, biological evaluation, and in silico studies
In the search for new anticancer agents, we synthesized a new series of thiazole derivatives
carried on thiadiazole-oxadiazole hybrid. Final compounds (5a–5i) were analyzed via 1H …
carried on thiadiazole-oxadiazole hybrid. Final compounds (5a–5i) were analyzed via 1H …
Synthesis, characterization, molecular docking and molecular dynamics simulations of novel 2, 5-disubstituted-1, 3, 4-thiadiazole derivatives as potential …
Designing multi-targeted drugs (MTD) for Alzheimer's disease (AD) is now one of the
priorities for medicinal chemists, as the disease has a complicated not fully understood …
priorities for medicinal chemists, as the disease has a complicated not fully understood …
Electrophysiological Assessment of newly synthesized 2, 3-Benzodiazepine derivatives for inhibiting the AMPA receptor Channel
Three major subtypes of ionotropic receptors regulate glutamatergic synaptic transmission,
one of which is α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors …
one of which is α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors …
Focusing on the moderately active compound (MAC) in the design and development of strategies to optimize the apoptotic effect by molecular mechanics techniques
Today, chemotherapeutic agents are mostly used to fight cancer in clinics. But even though
they have selectivity for cancer cells, their mechanism of action could result in necrosis …
they have selectivity for cancer cells, their mechanism of action could result in necrosis …
New N-(1,3,4-thiadiazole-2-yl)acetamide derivatives as human carbonic anhydrase I and II and acetylcholinesterase inhibitors
Various carbonic anhydrase (CA) enzyme isoforms are known today. In addition to the use
of CA inhibitors as diuretics, antiepileptics and antiglaucoma agents, the inhibition of other …
of CA inhibitors as diuretics, antiepileptics and antiglaucoma agents, the inhibition of other …
Biological activity evaluation of novel monoamine oxidase inhibitory compounds targeting Parkinson disease
Aim: Design of 5-methoxy benzofuran hybrids with 2-carbohydrazide and 2-(1, 3, 4-
oxadiazol-2-yl) as potential inhibitors of monoamine oxidase (MAO)-B targeting Parkinson …
oxadiazol-2-yl) as potential inhibitors of monoamine oxidase (MAO)-B targeting Parkinson …
[HTML][HTML] Structure–Activity relationship (SAR) of 18β-glycyrrhetinic acid derivatives on their antitumor activity through the PPARγ receptor and caspase-3 pathway
J Sun, Q Zheng, YH Zhang, CS Liu, CH Chen… - Journal of Saudi …, 2024 - Elsevier
Licorice is extensively utilized in the food industry, and glycyrrhetinic acid is among the most
critical active constituents in licorice. This ingredient has garnered increasing attention in …
critical active constituents in licorice. This ingredient has garnered increasing attention in …
[PDF][PDF] In silico studies and in vitro microsomal metabolism of potent MetAP2 inhibitor and in vivo tumor suppressor for prostate cancer: A thioether-triazole hybrid
Materials and methods: In the present study, the sulfoxide metabolite was synthesized,
purified and characterized by chromatographic and spectroscopic methods. SGK636, the S …
purified and characterized by chromatographic and spectroscopic methods. SGK636, the S …
Design and synthesis of phenoxy methyl‐oxadiazole compounds against Alzheimer's disease
This study examines the synthesis and evaluation of 11 newly developed compounds as
potential anti‐Alzheimer's agents that occur via cholinesterase and β‐secretase inhibition …
potential anti‐Alzheimer's agents that occur via cholinesterase and β‐secretase inhibition …