DMRT1: an ancient sexual regulator required for human gonadogenesis
D Zarkower, MW Murphy - Sexual Development, 2022 - karger.com
Transcriptional regulators related to the invertebrate sexual regulators doublesex and mab-3
occur throughout metazoans and control sex in most animal groups. Seven of these DMRT …
occur throughout metazoans and control sex in most animal groups. Seven of these DMRT …
Genetic regulation of vertebrate forebrain development by homeobox genes
Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …
Decoding cortical glial cell development
Mouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical
oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late …
oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late …
Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons
Projection neuron subtype identities in the cerebral cortex are established by expressing
pan-cortical and subtype-specific effector genes that execute terminal differentiation …
pan-cortical and subtype-specific effector genes that execute terminal differentiation …
Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition
MX Moreau, Y Saillour, AW Cwetsch, A Pierani… - …, 2021 - journals.biologists.com
In the developing cerebral cortex, how progenitors that seemingly display limited diversity
end up producing a vast array of neurons remains a puzzling question. The prevailing model …
end up producing a vast array of neurons remains a puzzling question. The prevailing model …
Cortical neural stem cell lineage progression is regulated by extrinsic signaling molecule sonic hedgehog
Neural stem cells (NSCs) in the prenatal neocortex progressively generate different
subtypes of glutamatergic projection neurons. Following that, NSCs have a major switch in …
subtypes of glutamatergic projection neurons. Following that, NSCs have a major switch in …
DNA conserved in diverse animals since the Precambrian controls genes for embryonic development
DNA that controls gene expression (eg enhancers, promoters) has seemed almost never to
be conserved between distantly related animals, like vertebrates and arthropods. This is …
be conserved between distantly related animals, like vertebrates and arthropods. This is …
Transcriptional network orchestrating regional patterning of cortical progenitors
AR Ypsilanti, K Pattabiraman… - Proceedings of the …, 2021 - National Acad Sciences
We uncovered a transcription factor (TF) network that regulates cortical regional patterning
in radial glial stem cells. Screening the expression of hundreds of TFs in the developing …
in radial glial stem cells. Screening the expression of hundreds of TFs in the developing …
Comprehensive analysis of DMRT3 as a potential biomarker associated with the immune infiltration in a pan-cancer analysis and validation in lung adenocarcinoma
D Yang, M Liu, J Jiang, Y Luo, Y Wang, H Chen, D Li… - Cancers, 2022 - mdpi.com
Simple Summary Doublesex and Mab-3 related Transcription Factor 3 (DMRT3) is
associated with the prognosis of some tumors. It is possible to explore the mechanisms and …
associated with the prognosis of some tumors. It is possible to explore the mechanisms and …
Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice
J Salomone, S Qin, TD Fufa, B Cain… - Genes & …, 2021 - genesdev.cshlp.org
How homeodomain proteins gain sufficient specificity to control different cell fates has been
a long-standing problem in developmental biology. The conserved Gsx homeodomain …
a long-standing problem in developmental biology. The conserved Gsx homeodomain …