This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

Ion channels in the plasma membrane of vascular muscle cells that form the walls of
resistance arteries and arterioles play a central role in the regulation of vascular tone …

Local intracellular Ca2+ transients, termed Ca2+ sparks, are caused by the coordinated
opening of a cluster of ryanodine-sensitive Ca2+ release channels in the sarcoplasmic …

Changes in membrane tension resulting from membrane stretch represent one of the key
elements in blood flow regulation in vascular smooth muscle. However, the molecular …

Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Blood pressure is regulated by a number of key molecules involving G-protein-coupled
receptors, ion channels and monomeric small G-proteins. The relative contribution of these …