Opioids are used for pain management despite the side effects that contribute to the opioid
crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the …

Chemogenetics is an approach for engineering proteins to enable their modulation by
otherwise inert small molecules. Although kinases, enzymes and ion channels have been …

The κ-opioid receptor (KOP) mediates the actions of opioids with hallucinogenic, dysphoric,
and analgesic activities. The design of KOP analgesics devoid of hallucinatory and …

DREADDs are chemogenetic tools widely used to remotely control cellular signaling,
neuronal activity, and behavior. Here we used a structure-based approach to develop a new …

The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not
only pain but also addiction and affective disorders. However, the development of KOR …

Apelin receptor (APJR) is a key regulator of human cardiovascular function and is activated
by two different endogenous peptide ligands, apelin and Elabela, each with different …

Opioid receptors are important drug targets for pain management, addiction, and mood
disorders. Although substantial research on these important subtypes of G protein-coupled …

Opioids such as morphine and oxycodone are analgesics frequently prescribed for the
treatment of moderate or severe pain. Unfortunately, these medications are associated with …

The κ-opioid receptor (KOR) has recently emerged as an alternative therapeutic target for
the development of pain medications, without deleterious side effects associated with the μ …

The neoclerodane diterpene salvinorin A, found in the leaves of Salvia divinorum, is a potent
κ-opioid receptor agonist, making it an attractive scaffold for development into a treatment for …