Role of tRNA modifications in human diseases
Transfer RNAs (tRNAs) are key for efficient and accurate protein translation. To be fully
active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates …
active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates …
Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
NAJ Krentz, AL Gloyn - Nature Reviews Endocrinology, 2020 - nature.com
Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has
both genetic and environmental risk factors, resulting in impaired glucose homeostasis …
both genetic and environmental risk factors, resulting in impaired glucose homeostasis …
[HTML][HTML] Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice
FY Wei, T Suzuki, S Watanabe… - The Journal of …, 2011 - Am Soc Clin Investig
The worldwide prevalence of type 2 diabetes (T2D), which is caused by a combination of
environmental and genetic factors, is increasing. With regard to genetic factors, variations in …
environmental and genetic factors, is increasing. With regard to genetic factors, variations in …
Comprehensive sub-mitochondrial protein map of the parasitic protist Trypanosoma brucei defines critical features of organellar biology
We have generated a high-confidence mitochondrial proteome (MitoTag) of the
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …
tRNA-derived small RNAs: biogenesis, modification, function and potential impact on human disease development
V Oberbauer, MR Schaefer - Genes, 2018 - mdpi.com
Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for
decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during …
decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during …
Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine
GC Mannino, F Andreozzi… - … /metabolism research and …, 2019 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global
epidemic. In order to achieve optimal glucose control, it is often necessary to rely on …
epidemic. In order to achieve optimal glucose control, it is often necessary to rely on …
An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery
Genome-wide association studies (GWASs) have increased our knowledge of loci
associated with a range of human diseases. However, applying such findings to elucidate …
associated with a range of human diseases. However, applying such findings to elucidate …
[HTML][HTML] Molybdenum cofactor biology, evolution and deficiency
The molybdenum cofactor (Moco) represents an ancient metal‑sulfur cofactor, which
participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global …
participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global …
Whole genome association studies of residual feed intake and related traits in the pig
SK Onteru, DM Gorbach, JM Young, DJ Garrick… - PloS one, 2013 - journals.plos.org
Background Residual feed intake (RFI), a measure of feed efficiency, is the difference
between observed feed intake and the expected feed requirement predicted from growth …
between observed feed intake and the expected feed requirement predicted from growth …
Molybdenum cofactor deficiency in humans
L Johannes, CY Fu, G Schwarz - Molecules, 2022 - mdpi.com
Molybdenum cofactor (Moco) deficiency (MoCD) is characterized by neonatal-onset
myoclonic epileptic encephalopathy and dystonia with cerebral MRI changes similar to …
myoclonic epileptic encephalopathy and dystonia with cerebral MRI changes similar to …