The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …

Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …

Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …

Stress triggers anticipatory physiological responses that promote survival, a phenomenon
termed allostasis. However, the chronic activation of energy-dependent allostatic responses …

Aging and age-related changes impact the quality of life (QOL) in elderly with a decline in
movement, cognitive abilities and increased vulnerability towards age-related diseases …

The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has
been linked to lifespan in nonhuman species and recently demonstrated to occur in rare …

Telomere attrition is a hallmark of biological aging, contributing to cellular replicative
senescence. However, few studies have examined the determinants of telomere attrition in …

Aging of human skin is a complex process leading to a decline in homeostasis and
regenerative potential of this tissue. Mitochondria are important cell organelles that have a …

Individuals with psychiatric disorders are at increased risk of age-related diseases and early
mortality. Recent studies demonstrate that this link between mental health and aging is …