Clonal hematopoiesis and atherosclerosis
Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously
unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic …
unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic …
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
MA Florez, BT Tran, TK Wathan, J DeGregori… - Cell Stem Cell, 2022 - cell.com
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …
of genetically variant hematopoietic cells that increases exponentially with age and is …
TET2-driven clonal hematopoiesis and response to canakinumab: an exploratory analysis of the CANTOS randomized clinical trial
EC Svensson, A Madar, CD Campbell, Y He… - JAMA …, 2022 - jamanetwork.com
Importance Clonal hematopoiesis of indeterminate potential (CHIP) is associated with
increased risk of atherosclerotic cardiovascular disease, and mouse experiments suggest …
increased risk of atherosclerotic cardiovascular disease, and mouse experiments suggest …
Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia
EJ Duncavage, A Bagg, RP Hasserjian… - Blood, The Journal …, 2022 - ashpublications.org
Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …
Premature menopause, clonal hematopoiesis, and coronary artery disease in postmenopausal women
Background: Premature menopause is an independent risk factor for cardiovascular disease
in women, but mechanisms underlying this association remain unclear. Clonal …
in women, but mechanisms underlying this association remain unclear. Clonal …
The impact of inflammation-induced tumor plasticity during myeloid transformation
Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal
outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of …
outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of …
Association of diet quality with prevalence of clonal hematopoiesis and adverse cardiovascular events
Importance Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of
somatic leukemogenic variations in hematopoietic stem cells, has been associated with …
somatic leukemogenic variations in hematopoietic stem cells, has been associated with …
Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis
Abstract Background and Aims Somatic mutations in the TET2 gene that lead to clonal
haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice …
haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice …
The role of the inflammasome in heart failure
J Wu, E Dong, Y Zhang, H Xiao - Frontiers in physiology, 2021 - frontiersin.org
Inflammation promotes the development of heart failure (HF). The inflammasome is a
multimeric protein complex that plays an essential role in the innate immune response by …
multimeric protein complex that plays an essential role in the innate immune response by …
Metabolism and chronic inflammation: the links between chronic heart failure and comorbidities
Z Li, H Zhao, J Wang - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Heart failure (HF) patients often suffer from multiple comorbidities, such as diabetes, atrial
fibrillation, depression, chronic obstructive pulmonary disease, and chronic kidney disease …
fibrillation, depression, chronic obstructive pulmonary disease, and chronic kidney disease …