Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

JM Simard, TA Kent, M Chen, KV Tarasov… - The Lancet …, 2007 - thelancet.com
Focal cerebral ischaemia and post-ischaemic reperfusion cause cerebral capillary
dysfunction, resulting in oedema formation and haemorrhagic conversion. There are …

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia …

YI Yang, EY Estrada, JF Thompson… - Journal of Cerebral …, 2007 - journals.sagepub.com
Matrix metalloproteinases (MMPs) disrupt the blood—brain barrier (BBB) during reperfusion.
Occludin and claudins are recently described tight junction proteins (TJPs) that form the …

Expression and activation of matrix metalloproteinase-2 and-9 in rat brain after transient focal cerebral ischemia

AM Planas, S Solé, C Justicia - Neurobiology of disease, 2001 - Elsevier
Matrix metalloproteinases (MMPs) degrade the extracellular matrix and carry out key
functions during development and after injury. By means of zymography, Western blot and …

Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats

C Justicia, J Panés, S Solé, A Cervera… - Journal of Cerebral …, 2003 - journals.sagepub.com
Matrix metalloproteinase-9 (MMP-9) activity increases in the brain during the first day after
focal ischemia and might be involved in the pathogenesis of tissue damage. We previously …

Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation

Y Ben-Yosef, N Lahat, S Shapiro, H Bitterman… - Circulation …, 2002 - Am Heart Assoc
Among the consequences resulting from the exposure of endothelial cells (ECs) to
ischemia/reperfusion is angiogenesis, involving degradation of vascular basement …

A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke

A Rosell, J Alvarez-Sabín, JF Arenillas, A Rovira… - Stroke, 2005 - Am Heart Assoc
Background and Purpose—Matrix metalloproteinases (MMPs) are involved in tissue
destruction produced by the neuroinflammatory response that follows ischemic stroke. In the …

Mechanisms of neuronal damage and neuroprotection underlying ischemia/reperfusion injury after physical exercise

D Dornbos III, Y Ding - Current Drug Targets, 2012 - ingentaconnect.com
The effects of exercise pre-conditioning on lessening the impact of ischemia/reperfusion
injury provide pivotal information and potential targets for future pharmacological …

Maternal immune activation induced by lipopolysaccharide triggers immune response in pregnant mother and fetus, and induces behavioral impairment in adult rats

LR Simões, G Sangiogo, MH Tashiro… - Journal of psychiatric …, 2018 - Elsevier
Evidence suggest that prenatal immune system disturbance contributes largely to the
pathophysiology of neuropsychiatric disorders. We investigated if maternal immune …

Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood–brain barrier dysfunction in stroke

M Guo, B Cox, S Mahale, W Davis, A Carranza… - Neuroscience, 2008 - Elsevier
Exercise reduces ischemia and reperfusion (I/R) injury in the rat stroke model. We
investigated whether pre-ischemic exercise ameliorates blood–brain barrier (BBB) …

Gelatinase B and TIMP‐1 are regulated in a cell‐and time‐dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia

S Rivera, C Ogier, J Jourquin, S Timsit… - European Journal of …, 2002 - Wiley Online Library
Matrix metalloproteinases (MMPs) belong to a large family of endopeptidases that regulate
the pericellular environment through the cleavage of protein components of the extracellular …