Translational and reverse translational research on the role of stress in drug craving and relapse
Rationale and background High relapse rates during abstinence are a pervasive problem in
drug addiction treatment. Relapse is often associated with stress exposure, which can …
drug addiction treatment. Relapse is often associated with stress exposure, which can …
Stress-related neuropeptides and addictive behaviors: beyond the usual suspects
Addictive disorders are chronic, relapsing conditions that cause extensive disease burden.
Genetic factors partly account for susceptibility to addiction, but environmental factors such …
Genetic factors partly account for susceptibility to addiction, but environmental factors such …
Evaluating the role of N-Acetyl-L-Tryptophan in the Aβ 1-42-induced neuroinflammation and cognitive decline in Alzheimer's disease
Abstract Alzheimer's disease (AD), a neurodegenerative condition previously known to affect
the older population, is also now seen in younger individuals. AD is often associated with …
the older population, is also now seen in younger individuals. AD is often associated with …
Tachykinin receptors as therapeutic targets in stress-related disorders
K Ebner, SB Sartori, N Singewald - Current pharmaceutical …, 2009 - ingentaconnect.com
The first report demonstrating the therapeutic efficacy of an orally applied neurokinin-1
(NK1) receptor antagonist in depression was published 10 years ago. Although there were …
(NK1) receptor antagonist in depression was published 10 years ago. Although there were …
Substance P and the neurokinin-1 receptor: the new CRF
Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that
preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and …
preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and …
Substance P in stress and anxiety: NK‐1 receptor antagonism interacts with key brain areas of the stress circuitry
K Ebner, P Muigg, G Singewald… - Annals of the New York …, 2008 - Wiley Online Library
In a previous work it was demonstrated that emotional stressors trigger the in vivo release of
the neuropeptide substance P (SP) in brain areas known to be implicated in stress and …
the neuropeptide substance P (SP) in brain areas known to be implicated in stress and …
Anxiety-rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety-and comorbid depression-like …
Adult neurogenesis has been implicated in affective disorders and the action of
antidepressants (ADs) although the functional significance of this association is still unclear …
antidepressants (ADs) although the functional significance of this association is still unclear …
Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429
JR Schank, CL Pickens, KE Rowe, K Cheng… - …, 2011 - Springer
Rationale Genetic inactivation or pharmacological antagonism of neurokinin 1 (NK1)
receptors blocks morphine and alcohol reward in rodents, while NK1 antagonism decreases …
receptors blocks morphine and alcohol reward in rodents, while NK1 antagonism decreases …
Dendritic spines of the medial amygdala: plasticity, density, shape, and subcellular modulation by sex steroids
The medial nucleus of the amygdala (MeA) is a complex component of the “extended
amygdala” in rats. Its posterodorsal subnucleus (MePD) has a remarkable expression of …
amygdala” in rats. Its posterodorsal subnucleus (MePD) has a remarkable expression of …
Ionic signalling mechanisms involved in neurokinin‐3 receptor‐mediated augmentation of fear‐potentiated startle response in the basolateral amygdala
CA Boyle, B Hu, KL Quaintance… - The Journal of …, 2022 - Wiley Online Library
The tachykinin peptides include substance P (SP), neurokinin A and neurokinin B, which
interact with three G‐protein‐coupled neurokinin receptors, NK1Rs, NK2Rs and NK3Rs …
interact with three G‐protein‐coupled neurokinin receptors, NK1Rs, NK2Rs and NK3Rs …