Aging is characterized by a progressive loss of tissue and organ function due to genetic and
environmental factors, nutrition, and lifestyle. Oxidative stress is one the most important …

Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

Objective To assess the association between learning disability and risk of hospital
admission and death from covid-19 in England among adults and children. Design …

Individuals with Down syndrome show cellular and clinical features of dysregulated aging of
the immune system, including a shift from naïve to memory T cells and increased incidence …

Epigenetic clocks were initially developed to track chronological age, but accumulating
evidence indicates that they can also predict biological age. They are usually based on the …

The gut microbiome is undoubtedly a key modulator of human health, which can promote or
impair homeostasis throughout life. This is even more relevant in old age, when there is a …

Advances in imaging, catheter-based interventions, congenital heart disease surgery, and
clinical management of congenital heart disease (CHD) have yielded a dramatic change in …

Nowadays, aging is understood as a dynamic and multifaceted dysregulation process that
spares almost no human organ or cell. The immune system being among the most affected …

The phenotype of old people is the result of the capability of the body to respond/adapt to
cellular and molecular insults continuously occurring in all tissues and organs (damaging …

Down syndrome (DS), caused by trisomy 21 (T21), results in immune and metabolic
dysregulation. People with DS experience co-occurring conditions at higher rates than the …