Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation

SS Swain, S Pati, T Hussain - European Journal of Medicinal Chemistry, 2022 - Elsevier
Today, tuberculosis (TB) caused by the acid-fast bacilli, Mycobacterium tuberculosis (Mtb) is
the most infectious killer disease globally with high morbidity and mortality rates. The rapid …

Diverse Pharmacological Potential of different Substituted Pyrazole Derivatives

M Asif, M Almehmadi, AA Alsaiari… - Current Organic …, 2024 - ingentaconnect.com
The chemistry of heterocyclic compounds has been a topic of research interest. Some five-
membered heterocyclic compounds have been the subject of extensive research due to their …

Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

A Kapri, N Gupta, S Nain - Pharmaceutical Chemistry Journal, 2024 - Springer
Among a large number of nitrogen-containing heterocyclic compounds, pyrazole is a
privileged scaffold with the molecular formula C3H3N2H. It consists of a five-membered ring …

Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors

HO Tawfik, TF El-Moselhy, NS El-Din… - Bioorganic & Medicinal …, 2019 - Elsevier
A series of twenty-one 3, 4-dihydropyrimidine derivatives bearing the heterocyclic 1, 3-
benzodioxole at position 4 in addition to different substituents at positions 2, 3 and 5 were …

Synthesis of 1, 3-benzodioxole-based procaine-tagged ionic liquids and investigation of its physiochemical and anti-cancer properties against A549 cells

N Kumari, S Agrawal, M Maruthi, A Sarkar… - Journal of Molecular …, 2023 - Elsevier
There is significant interest in ionic liquids based on 1, 3-benzodioxole as potential leads for
novel anticancer agents. Herein, we report the design and development of a series of 1, 3 …

Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors

MH El‐Hamamsy, NA Sharafeldin… - Archiv der …, 2020 - Wiley Online Library
Lung, colorectal, and breast cancers are the top three types of cancer by incidence and are
responsible for one‐third of the cancer incidence and mortality. A series of 18 3, 4 …

Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment

IAY Ghannam, IH Ali, RZ Batran, MT Abo-elfadl… - Medicinal Chemistry …, 2024 - Springer
In this study, chalcones 5, and 6 and pyrazolines 7, and 8 were designed and synthesized
as combrestatin A-4 (CA-4) analogues. The anticancer effect of the synthesized compounds …

Changes in the quality of refined fish oil in an accelerated storage study

K Chakraborty, D Joseph, D Joseph - Journal of Aquatic Food …, 2016 - Taylor & Francis
The aim of this study was to prepare the refined oil derived from Sardinella longiceps by a
step-wise procedure of degumming, bleaching, and deodorization. The refined sardine oil …

In vitro biological evaluation of benzodioxol derivatives as antimicrobial and antioxidant agents

A Khalil, N Jaradat, M Hawash, L Issa - Arabian Journal for Science and …, 2021 - Springer
Abstract The 1, 3-benzodioxol moiety present in safrole, apiole, and myristicin essential oils
and benzodioxol derivatives have shown a wide range of biological activities including …

Design and synthesis of new quinazolinone derivatives: investigation of antimicrobial and biofilm inhibition effects

RM Hassan, H Yehia, MF El-Behairy… - Molecular Diversity, 2024 - Springer
Abstract New quinazolin-4-ones 9–32 were synthesized in an attempt to overcome the life-
threatening antibiotic resistance phenomenon. The antimicrobial screening revealed that …