The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

MR Ananth, P Rajebhosale, R Kim… - Nature Reviews …, 2023 - nature.com
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Mechanisms and treatment strategies of organophosphate pesticide induced neurotoxicity in humans: A critical appraisal

SY Ganie, D Javaid, YA Hajam, MS Reshi - Toxicology, 2022 - Elsevier
Organophosphates (OPs) are commonly used pesticides worldwide. Humans are exposed
to OPs via different routes viz., the respiratory tract, gastrointestinal tract, and dermal …

Informing deep neural networks by multiscale principles of neuromodulatory systems

J Mei, E Muller, S Ramaswamy - Trends in Neurosciences, 2022 - cell.com
Our brains have evolved the ability to configure and adapt their processing states to match
the unique challenges of acting and learning in diverse environments and behavioral …

G-protein-coupled receptors in CNS: a potential therapeutic target for intervention in neurodegenerative disorders and associated cognitive deficits

S Azam, ME Haque, M Jakaria, SH Jo, IS Kim, DK Choi - Cells, 2020 - mdpi.com
Neurodegenerative diseases are a large group of neurological disorders with diverse
etiological and pathological phenomena. However, current therapeutics rely mostly on …

Are kynurenines accomplices or principal villains in dementia? Maintenance of kynurenine metabolism

M Tanaka, Z Bohár, L Vécsei - Molecules, 2020 - mdpi.com
Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive
and social functions, progressing severely enough to interfere with daily life. Alzheimer's …

Environmental exposures and sleep outcomes: a review of evidence, potential mechanisms, and implications

J Liu, L Ghastine, P Um, E Rovit, T Wu - Environmental research, 2021 - Elsevier
Environmental exposures and poor sleep outcomes are known to have consequential
effects on human health. This integrative review first seeks to present and synthesize …

Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

G Bjørklund, H Antonyak, A Polishchuk… - Archives of …, 2022 - Springer
Methylmercury (MeHg) is a global environmental pollutant with neurotoxic effects. Exposure
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …

Local thyroid hormone action in brain development

A Alcaide Martin, S Mayerl - International Journal of Molecular Sciences, 2023 - mdpi.com
Proper brain development essentially depends on the timed availability of sufficient amounts
of thyroid hormone (TH). This, in turn, necessitates a tightly regulated expression of TH …

Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region

A Romani, A Antonietti, D Bella, J Budd… - Plos …, 2024 - journals.plos.org
The CA1 region of the hippocampus is one of the most studied regions of the rodent brain,
thought to play an important role in cognitive functions such as memory and spatial …