Killing of HIV-infected cells by CD8+ T-cells imposes strong selection pressure on the virus
toward escape. The HLA class I molecules that are successful in mediating some degree of …

The evolutionary origin of the variants of concern (VOCs) of SARS-CoV-2, characterized by
a large number of new substitutions and strong changes in virulence and transmission rate …

HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we
evaluate the impact on viral control and disease progression of transmitted polymorphisms …

A severe bottleneck exists during HIV-1 mucosal transmission. However, viral properties that
determine HIV-1 transmissibility are not fully elucidated. We identified multiple …

Over the past few decades the extent to which cytotoxic T lymphocytes (CTLs) control human
immunodeficiency virus (HIV) replication has been studied extensively, yet their role and …

Following transmission, HIV-1 adapts in the new host by acquiring mutations that allow it to
escape from the host immune response at multiple epitopes. It also reverts mutations …

The extensive hypervariability of human immunodeficiency virus type-1 (HIV-1) populations
represents a major barrier against the success of currently available antiretroviral therapy …

Objective Viral fitness plays an important role in HIV-1 evolution, transmission and
pathogenesis. However, how mutations accumulated during early infection affect viral fitness …

While prior studies have demonstrated that CD8 T cell responses to cryptic epitopes (CE)
are readily detectable during HIV-1 infection, their ability to drive escape mutations following …

The suppression of viral loads and identification of selection signatures in non-human
primates after challenge are indicators for effective human immunodeficiency virus …