Bottlebrush polymers: From controlled synthesis, self-assembly, properties to applications

Z Li, M Tang, S Liang, M Zhang, GM Biesold… - Progress in Polymer …, 2021 - Elsevier
Bottlebrush polymers (BBPs) have emerged as intriguing class of materials for an array of
applications, including supersoft elastomers, organic optoelectronics, templates for crafting …

Nanoantibiotics: Functions and properties at the nanoscale to combat antibiotic resistance

MM Mamun, AJ Sorinolu, M Munir… - Frontiers in …, 2021 - frontiersin.org
One primary mechanism for bacteria developing resistance is frequent exposure to
antibiotics. Nanoantibiotics (nAbts) is one of the strategies being explored to counteract the …

Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures

Y Jiang, W Zheng, K Tran, E Kamilar, J Bariwal… - Nature …, 2022 - nature.com
To dissect the antibiotic role of nanostructures from chemical moieties belligerent to both
bacterial and mammalian cells, here we show the antimicrobial activity and cytotoxicity of …

Mechanism of Action and Design of Potent Antibacterial Block Copolymer Nanoparticles

HC Parkin, STG Street, B Gowen… - Journal of the …, 2024 - ACS Publications
Self-assembled polymer nanoparticles are promising antibacterials, with nonspherical
morphologies of particular interest as recent work has demonstrated enhanced antibacterial …

Amphiphilic polymer therapeutics: An alternative platform in the fight against antibiotic resistant bacteria

H Takahashi, GA Caputo, K Kuroda - Biomaterials Science, 2021 - pubs.rsc.org
As we are on the cusp of the “post-antibiotic” era due to rapid spread of drug resistant
bacteria, there is an urgent need for new antimicrobials that are not susceptible to bacterial …

Impact of multivalence and self-assembly in the design of polymeric antimicrobial peptide mimics

S Laroque, M Reifarth, M Sperling… - … applied materials & …, 2020 - ACS Publications
Antimicrobial resistance is an increasingly serious challenge for public health and could
result in dramatic negative consequences for the health care sector during the next decades …

Shape matters: Highly selective Antimicrobial Bottle Brush copolymers via a one-pot RAFT polymerization approach

AC Lehnen, AM Bapolisi, M Krass, A AlSawaf… - …, 2022 - ACS Publications
The one-pot synthesis of antimicrobial bottle brush copolymers is presented. Reversible
addition–fragmentation chain-transfer (RAFT) polymerization is used for the production of …

Anisotropy in Antimicrobial Bottle Brush Copolymers and Its Influence on Biological Activity

AC Lehnen, S Kogikoski Jr, T Stensitzki… - Advanced Functional …, 2024 - Wiley Online Library
Antimicrobial polymers are a promising alternative to conventional antibiotics in the fight
against antimicrobial resistance. Cationic bottle brush copolymers have shown to be …

Cationic bottlebrush copolymers from partially hydrolyzed poly (oxazoline) s

TG Floyd, S Hakkinen, SCL Hall, RM Dalgliesh… - …, 2021 - ACS Publications
Cationically charged bottlebrush copolymers were produced by hydrolysis of poly (2-ethyl-2-
oxazoline)(PEtOx). The cationic ring-opening polymerization of EtOx was initiated using a …

The function of peptide-mimetic anionic groups and salt bridges in the antimicrobial activity and conformation of cationic amphiphilic copolymers

R Bhat, LL Foster, G Rani, S Vemparala, K Kuroda - RSC advances, 2021 - pubs.rsc.org
Herein we report the synthesis of ternary statistical methacrylate copolymers comprising
cationic ammonium (amino-ethyl methacrylate: AEMA), carboxylic acid (propanoic acid …