Functional peptides for siRNA delivery
Abstract siRNA is considered as a potent therapeutic agent because of its high specificity
and efficiency in suppressing genes that are overexpressed during disease development …
and efficiency in suppressing genes that are overexpressed during disease development …
Bacteriophages and phage-inspired nanocarriers for targeted delivery of therapeutic cargos
The main goal of drug delivery systems is to target therapeutic cargoes to desired cells and
to ensure their efficient uptake. Recently a number of studies have focused on designing bio …
to ensure their efficient uptake. Recently a number of studies have focused on designing bio …
Restoration of sinusoid fenestrae followed by targeted nanoassembly delivery of an anti‐fibrotic agent improves treatment efficacy in liver fibrosis
F Li, Y Zhao, Z Cheng, Y Wang, Y Yue… - Advanced …, 2023 - Wiley Online Library
During the onset of liver fibrosis, capillarized liver sinusoidal endothelial cells (LSECs) limit
substance exchange between the blood and the Disse space, further accelerating hepatic …
substance exchange between the blood and the Disse space, further accelerating hepatic …
siRNA-and miRNA-based therapeutics for liver fibrosis
Liver fibrosis is a wound-healing process induced by chronic liver injuries, such as
nonalcoholic steatohepatitis, hepatitis, alcohol abuse, and metal poisoning. The …
nonalcoholic steatohepatitis, hepatitis, alcohol abuse, and metal poisoning. The …
Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents
Y Lin, Y Lu, X Li - Journal of Drug Targeting, 2020 - Taylor & Francis
A primary focus of pharmacology is the accurate transport of drugs from the peripheral veins
and their delivery to specific tissues and organs. Exosomes are nanoscale extracellular …
and their delivery to specific tissues and organs. Exosomes are nanoscale extracellular …
Enhanced sensitivity of tumor cells to autophagy inhibitors using fasting-mimicking diet and targeted lysosomal delivery nanoplatform
Autophagy is one of the key pathways for tumor cell survival and proliferation. Therefore,
inhibition of autophagy has been extensively studied for cancer therapy. However, current …
inhibition of autophagy has been extensively studied for cancer therapy. However, current …
Comparison of avidin, neutravidin, and streptavidin as nanocarriers for efficient siRNA delivery
Protein-based drug delivery carrier has been one of the most employed modalities in
biopharmaceuticals. In this study, we have compared avidin and its two analogues …
biopharmaceuticals. In this study, we have compared avidin and its two analogues …
Recapitulating dynamic ECM ligand presentation at biomaterial interfaces: Molecular strategies and biomedical prospects
W He, Q Wang, X Tian, G Pan - Exploration, 2022 - Wiley Online Library
The extracellular matrix (ECM) provides not only physical support for the tissue structural
integrity, but also dynamic biochemical cues capable of regulating diverse cell behaviors …
integrity, but also dynamic biochemical cues capable of regulating diverse cell behaviors …
Emerging landscape of cell penetrating peptide in reprogramming and gene editing
The plasma membrane remains a major barrier for intracellular drug delivery, to overcome
this issue, a variety of approaches have been developed and used to deliver therapeutic …
this issue, a variety of approaches have been developed and used to deliver therapeutic …
Discovery of a polystyrene binding peptide isolated from phage display library and its application in peptide immobilization
X Qiang, K Sun, L Xing, Y Xu, H Wang, Z Zhou… - Scientific reports, 2017 - nature.com
Phage peptide display is a powerful technique for discovery of various target-specific
ligands. However, target-unrelated peptides can often be obtained and cause ambiguous …
ligands. However, target-unrelated peptides can often be obtained and cause ambiguous …