Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

Background: Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma
pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are …

For patients with hereditary retinal diseases, retinal gene therapy offers significant promise
for the prevention of retinal degeneration. While adeno-associated virus (AAV)-based …

Caveolae, specialized plasma membrane invaginations present in most cell types, play
important roles in multiple cellular processes including cell signaling, lipid uptake and …

Polymorphisms in the CAV1/2 genes that encode signature proteins of caveolae are
associated with glaucoma, the second leading cause of blindness worldwide, and with its …

Caveolae are specialized, invaginated plasma membrane domains that are defined
morphologically and by the expression of signature proteins called, caveolins. Caveolae …

The earliest and most significant change in diabetic retinopathy (DR) is blood-retinal barrier
(BRB) dysfunction, followed by two main pathologies that may cause severe visual …

Caveolin-1 associates with the endo/lysosomal machinery of cells in culture, suggesting that
it functions at these organelles independently of its contribution to cell surface caveolae …

Over‐and underexposure to cholesterol activates glia in neurodegenerative brain and
retinal diseases but the molecular targets of cholesterol in glial cells are not known. Here …