Rare diseases are life-threatening or chronically debilitating low-prevalent disorders caused
by pathogenic mutations or particular environmental insults. Due to their high complexity …

Accurate and rapid diagnosis of amyotrophic lateral sclerosis (ALS) is essential in order to
provide accurate information for patient and family, to avoid time-consuming investigations …

The continuous adherence to the conventional “one target, one drug” paradigm has failed so
far to provide effective therapeutic solutions for heterogeneous and multifactorial diseases …

Increasing evidence shows that disease spreading in amyotrophic lateral sclerosis (ALS)
follows a preferential pattern with more frequent involvement of contiguous regions from the …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by TDP-43 inclusions in the cortical and spinal motor neurons. It remains …

Amyotrophic Lateral Sclerosis (ALS) is characterized by the progressive degeneration of
upper or lower motor neurons, leading to muscle wasting and paralysis, resulting in …

Background Currently, there is a lack of knowledge concerning where the pathological
process starts and how the neurodegeneration spreads during the course of amyotrophic …

Background Neuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS)
indicates that neurodegeneration may spread corticofugally. Methods We conducted an …

Background Actigraphy has been proposed as a measure for tracking functional decline and
disease progression in patients with Motor Neuron Disease (MND). There is, however, little …

Background and purpose Clarification of propagation patterns in amyotrophic lateral
sclerosis (ALS) is challenging, but understanding these has implications for individual …