Maintenance of the cellular redox balance is crucial for cell survival. An increase in reactive
oxygen, nitrogen, or chlorine species can lead to oxidative stress conditions, potentially …

Extracellular stimuli elicit a variety of responses, such as cell proliferation and differentiation,
through the cellular signalling system. Binding of growth factors to the respective receptor …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

▪ Abstract The mammalian thioredoxins are a family of small (approximately 12 kDa) redox
proteins that undergo NADPH-dependent reduction by thioredoxin reductase and in turn …

Gene expression is modulated by both physiological signals (hormones, cytokines, etc.) and
environmental stimuli (physical parameters, xenobiotics, etc.). Oxidative stress appears to be …

The thioredoxins are ubiquitous proteins containing a conserved-Trp-Cys-Gly-Pro-Cys-Lys-
redox catalytic site. Mammalian thioredoxin family members include thioredoxin-1 (Trx1) …

Redox regulation has been perceived as a simple on-off switch in proteins (corresponding to
reduced and oxidized states). Using the transcription factor OxyR as a model, we have …

This review describes production and effects of reactive oxygen species (ROS) on airway
function. ROS are important in many physiological processes but can also have detrimental …

ABSTRACT A growing body of evidence suggests that the cellular response to oxidative and
nitrosative stress is primarily regulated at the level of transcription. Posttranslational …

There has been increasing interest, in recent years, in the possibility that reactive
oxygen/nitrogen species (ROS/RNS) act as signals, or mediators of changes, in cell function …