Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications

DW Kim, M Staples, K Shinozuka, P Pantcheva… - International journal of …, 2013 - mdpi.com
Wharton's jelly (WJ) is a gelatinous tissue within the umbilical cord that contains
myofibroblast-like stromal cells. A unique cell population of WJ that has been suggested as …

The heterogeneity of mesenchymal stem cells: An important issue to be addressed in cell therapy

J Li, Z Wu, L Zhao, Y Liu, Y Su, X Gong, F Liu… - Stem Cell Research & …, 2023 - Springer
With the continuous improvement of human technology, the medical field has gradually
moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool …

In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment

KC Russell, DG Phinney, MR Lacey, BL Barrilleaux… - Stem …, 2010 - academic.oup.com
In regenerative medicine, bone marrow is a promising source of mesenchymal stem cells
(MSCs) for a broad range of cellular therapies. This research addresses a basic prerequisite …

Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue

CK Rebelatto, AM Aguiar, MP Moretao… - Experimental …, 2008 - journals.sagepub.com
Mesenchymal stem cells (MSCs) have been investigated as promising candidates for use in
new cell-based therapeutic strategies such as mesenchyme-derived tissue repair. MSCs are …

MSCs: biological characteristics, clinical applications and their outstanding concerns

YL Si, YL Zhao, HJ Hao, XB Fu, WD Han - Ageing research reviews, 2011 - Elsevier
Mesenchymal stem cells (MSCs) are multi-potent adult stem cells harboring multi-lineage
differentiation potential and immunosuppressive properties that make MSCs an ideal …

Stem cells in bone tissue engineering

JM Seong, BC Kim, JH Park, IK Kwon… - Biomedical …, 2010 - iopscience.iop.org
Bone tissue engineering has been one of the most promising areas of research, providing a
potential clinical application to cure bone defects. Recently, various stem cells including …

Novel sources of fetal stem cells: where do they fit on the developmental continuum?

KI Pappa, NP Anagnou - Regenerative medicine, 2009 - Taylor & Francis
The recent isolation of fetal stem cells from several sources either at the early stages of
development or during the later trimesters of gestation, sharing similar growth kinetics and …

Mesenchymal stem cells increase hippocampal neurogenesis and neuronal differentiation by enhancing the Wnt signaling pathway in an Alzheimer's disease model

SH Oh, HN Kim, HJ Park, JY Shin… - Cell …, 2015 - journals.sagepub.com
Neurogenesis in the subgranular zone of the hippocampal dentate gyrus may act as an
endogenous repair mechanism in Alzheimer's disease (AD), and the Wnt signaling pathway …

[HTML][HTML] Mesenchymal stromal cells from human perinatal tissues: From biology to cell therapy

K Bieback, I Brinkmann - World journal of stem cells, 2010 - ncbi.nlm.nih.gov
Cell-based regenerative medicine is of growing interest in biomedical research. The role of
stem cells in this context is under intense scrutiny and may help to define principles of organ …

Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity

Y Huang, Q Li, K Zhang, M Hu, Y Wang, L Du… - Cell death & …, 2019 - nature.com
Mesenchymal stem cells (MSCs) are a population of multipotent cells with a superior ability
to promote tissue repair by regulating regeneration and inflammation. Effective application of …