Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to
recognize a homologous mRNA sequence in the cell and induce its degradation. The main …

Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …

Well over a hundred reports have been published describing use of synthetic small-
interfering RNAs (siRNAs) in animals. The majority of these reports employed unmodified …

RNA engineering for nanotechnology and medical applications is an exciting emerging
research field. RNA has intrinsically defined features on the nanometre scale and is a …

RNA interference (RNAi) has been extensively employed for in vivo research since its use
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …

Instability and inadequate biodistribution of double-stranded RNA are major drawbacks to
the clinical use of RNA interference. This work compares chemical modification and …

Although fluorine is not a naturally occurring component of genetic material, fluorine-
containing drugs have many medical applications.[1] Fluorine is highly electronegative, and …

Various chemical modifications are currently being evaluated for improving the efficacy of
short interfering RNA (siRNA) duplexes as antisense agents for gene silencing in vivo …

Oligonucleotides including antisense oligonucleotides and siRNA are emerging as
promising therapeutic agents against a variety of diseases. Effective delivery of these …

Rationale: POSTN (Periostin) is an ECM (extracellular matrix) protein involved in tissue
remodeling in response to injury and a contributing factor in tumorigenesis, suggesting that …