Mammalian Krüppel-like factors in health and diseases
BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …
processes that include proliferation, differentiation, growth, development, survival, and …
Physiological functions of the HECT family of ubiquitin ligases
The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and
targets them for degradation or for other cellular fates. The HECT enzymes, including Nedd4 …
targets them for degradation or for other cellular fates. The HECT enzymes, including Nedd4 …
Krüppel-like factors in cancer
MP Tetreault, Y Yang, JP Katz - Nature Reviews Cancer, 2013 - nature.com
Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with
diverse and essential functions in a multitude of cellular processes, including proliferation …
diverse and essential functions in a multitude of cellular processes, including proliferation …
[HTML][HTML] Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis
Y Hirata, K Nomura, Y Senga, Y Okada, K Kobayashi… - JCI insight, 2019 - ncbi.nlm.nih.gov
Diabetes mellitus is associated with various disorders of the locomotor system including the
decline in mass and function of skeletal muscle. The mechanism underlying this association …
decline in mass and function of skeletal muscle. The mechanism underlying this association …
Targeting matrix metalloproteinases by E3 ubiquitin ligases as a way to regulate the tumor microenvironment for cancer therapy
J Liu, T Chen, S Li, W Liu, P Wang, G Shang - Seminars in cancer biology, 2022 - Elsevier
The tumor microenvironment (TME) plays an important role in neoplastic development.
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …
Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells
N Sun, NJ Panetta, DM Gupta… - Proceedings of the …, 2009 - National Acad Sciences
Ectopic expression of transcription factors can reprogram somatic cells to a pluripotent state.
However, most of the studies used skin fibroblasts as the starting population for …
However, most of the studies used skin fibroblasts as the starting population for …
[HTML][HTML] The HECT family of E3 ubiquitin ligases: multiple players in cancer development
The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial
signaling pathways implicated in tumorigenesis is presently an area of intense research and …
signaling pathways implicated in tumorigenesis is presently an area of intense research and …
Coping with stress: multiple ways to activate p53
HF Horn, KH Vousden - Oncogene, 2007 - nature.com
Over the years, p53 has been shown to sit at the centre of an increasingly complex web of
incoming stress signals and outgoing effector pathways. The number and diversity of stress …
incoming stress signals and outgoing effector pathways. The number and diversity of stress …
The roles and regulation of the KLF5 transcription factor in cancers
Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …
that KLF5 regulates the expression of a large number of new target genes and participates …
BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5
The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes
breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in …
breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in …