Mammalian oocytes undergo two rounds of developmental arrest during maturation: at the
diplotene of the first meiotic prophase and metaphase of the second meiosis. These arrests …

Objectives Reprogramming of cellular metabolism is profoundly implicated in tumorigenesis
and can be exploited to cancer treatment. Cancer cells are known for their propensity to use …

The reproductive and endocrine functions of the ovary involve spatially defined interactions
among specialized cell populations. Despite the ovary's importance in fertility and endocrine …

In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased
oxidative damage during IVF may be involved in tumor formation. However, the molecular …

We aimed to survey the monogenic causes of disorders of sex development (DSD) and
thereby its prevalence in India. This study revealed mutations resulting in androgen …

Introduction: Ovarian aging is characterized by a gradual decline in quantity and quality of
oocytes and lower chance of fertility. Better understanding the genetic modulation during …

Structural causal models (SCMs) are widely used in various disciplines to represent causal
relationships among variables in complex systems. Unfortunately, the underlying causal …

Oocytes are indispensable for mammalian life. Thus, it is important to understand how
mature oocytes are generated. As a critical stage of oocytes development, meiosis has been …

The loss of genetic variability in livestock populations bred under strict selection processes
is a growing concern, as it may lead to increased inbreeding values and lower fertility, as a …

During reproductive age, approximately one in seven couples are confronted with fertility
problems. While the aetiology is diverse, including infections, metabolic diseases, hormonal …