Diabetic vascular complications can affect both microvascular and macrovascular. Diabetic
microvascular complications, such as diabetic nephropathy, diabetic retinopathy, diabetic …

Abstract Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling,
which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various …

Alveolar epithelial cell (AEC) senescence is considered to be a universal pathological
feature of many chronic pulmonary diseases. Our previous study found that …

Aim Patients with diabetes mellitus have poor prognosis after myocardial ischemic injury.
However, the mechanism is unclear and there are no related therapies. We aimed to identify …

Summary Background Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid
that may impact atherosclerosis, and animal experimental studies suggest EETs protect …

Diabetic cardiomyopathy (DCM) is a metabolic disease and a leading cause of heart failure
among people with diabetes. Mass spectrometry imaging (MSI) is a versatile technique …

Atherosclerosis (AS) is a metabolic disorder commonly correlated with a high-fat diet (HFD).
There are many endogenous metabolic changes associated with AS development. Gualou …

Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized
by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and …

Abstract Diabetic Peripheral Neuropathy (DPN), highly prevalent among patients with
diabetes, is characterized by peripheral nerve dysfunction. Reactive Oxygen Species (ROS) …

Diabetes is associated with decreased epoxyeicosatrienoic acid (EET) bioavailability and
increased levels of glomerular vascular endothelial growth factor A (VEGF-A) expression …