[HTML][HTML] GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

ER Kramer, B Liss - Febs Letters, 2015 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal
together or independently to fulfill many important functions in the midbrain dopaminergic …

Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease

G Burzynski, IT Shepherd… - Neurogastroenterology & …, 2009 - Wiley Online Library
The enteric nervous system (ENS) is the largest and most complicated subdivision of the
peripheral nervous system. Its action is necessary to regulate many of the functions of the …

Noncanonical function of folate through folate receptor 1 during neural tube formation

OA Balashova, AA Panoutsopoulos, O Visina… - Nature …, 2024 - nature.com
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects
consisting in the failure of the neural tube to form and close. The mechanisms underlying …

[HTML][HTML] Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function

BA Pierchala, MR Muñoz, CC Tsui - Kidney international, 2010 - Elsevier
Podocytes are morphologically complex cells, the junctions of which form critical elements of
the final filtration barrier. Disruption of their foot processes and slit diaphragms occur early in …

cindr, the Drosophila homolog of the CD2AP Alzheimer's disease risk gene, is required for synaptic transmission and proteostasis

SA Ojelade, TV Lee, N Giagtzoglou, L Yu, B Ugur, Y Li… - Cell reports, 2019 - cell.com
The Alzheimer's disease (AD) susceptibility gene, CD2-associated protein (CD2AP),
encodes an actin binding adaptor protein, but its function in the nervous system is largely …

Differential recognition preferences of the three Src homology 3 (SH3) domains from the adaptor CD2-associated protein (CD2AP) and direct association with Ras and …

E Rouka, PC Simister, M Janning, J Kumbrink… - Journal of Biological …, 2015 - ASBMB
CD2AP is an adaptor protein involved in membrane trafficking, with essential roles in
maintaining podocyte function within the kidney glomerulus. CD2AP contains three Src …

The adaptor protein CD2AP is a coordinator of neurotrophin signaling-mediated axon arbor plasticity

BJ Harrison, G Venkat, JL Lamb, TH Hutson… - Journal of …, 2016 - Soc Neuroscience
Growth of intact axons of noninjured neurons, often termed collateral sprouting, contributes
to both adaptive and pathological plasticity in the adult nervous system, but the intracellular …

Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption

S Barak, S Ahmadiantehrani, V Kharazia… - Translational …, 2011 - nature.com
Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the
survival and maintenance of the midbrain dopaminergic (DA-ergic) neurons. Activation of …

Noncanonical function of folate through folate receptor 1 during neural tube formation.

A Panoutsopoulos, O Visina, J Selhub… - Nature …, 2024 - escholarship.org
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects
consisting in the failure of the neural tube to form and close. The mechanisms underlying …

Methylation of the epigenetic JMJD2D protein by SET7/9 promotes prostate tumorigenesis

R Gu, TD Kim, H Jiang, S Shin, S Oh… - Frontiers in …, 2023 - frontiersin.org
How the function of the JMJD2D epigenetic regulator is regulated or whether it plays a role
in prostate cancer has remained elusive. We found that JMJD2D was overexpressed in …