Altered metabolism in cancer: Insights into energy pathways and therapeutic targets

M Tufail, CH Jiang, N Li - Molecular Cancer, 2024 - Springer
Cancer cells undergo significant metabolic reprogramming to support their rapid growth and
survival. This study examines important metabolic pathways like glycolysis, oxidative …

Targeting autophagy and lipid metabolism in cancer stem cells

B Chakravarti, JA Siddiqui, RA Sinha, S Raza - Biochemical pharmacology, 2023 - Elsevier
Cancer stem cells (CSCs) are a subset of cancer cells with self-renewal ability and tumor
initiating properties. Unlike the other non-stem cancer cells, CSCs resist traditional therapy …

Targeting SLP2-mediated lipid metabolism reprograming restricts proliferation and metastasis of hepatocellular carcinoma and promotes sensitivity to Lenvatinib

Y Liu, L Sun, H Guo, S Zhou, C Wang, C Ji, F Meng… - Oncogene, 2023 - nature.com
SLP2, a protein located on mitochondrial, has been shown to be associated with
mitochondrial biosynthesis. Here we explored the potential mechanisms by which SLP2 …

Metabolic vulnerabilities in cancer: A new therapeutic strategy

M El-Tanani, SA Rabbani, Y El-Tanani… - Critical Reviews in …, 2024 - Elsevier
Cancer metabolism is now a key area for therapeutic intervention, targeting unique
metabolic reprogramming crucial for tumor growth and survival. This article reviews the …

Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential

YJ Cheng, F Fan, Z Zhang, H Zhang - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Brain metastasis is a highly traumatic event in the progression of malignant
tumors, often symbolizing higher mortality. Metabolic alterations are hallmarks of cancer …

Impaired hepatic lipid metabolism and biomarkers in fatty liver diseases

FS Teixeira, LL Pimentel, ME Pintado… - Biochimie, 2023 - Elsevier
The liver plays a crucial role in lipid metabolism and metabolic homeostasis. Non-Alcoholic
Fatty Liver Disease (NAFLD) is the most common chronic liver disease worldwide and …

[HTML][HTML] Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling …

X Zeng, G Gong, K Ganesan, Y Wen, Q Liu… - Journal of Traditional …, 2023 - Elsevier
Background and aim Triple-negative breast cancer (TNBC) is a highly invasive type of
breast cancer with a poor prognosis. Currently, there are no effective management …

The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications

B Deng, W Kong, X Shen, C Han, Z Zhao… - Journal of Translational …, 2024 - Springer
Lipid metabolism is widely reprogrammed in tumor cells. Lipid droplet is a common
organelle existing in most mammal cells, and its complex and dynamic functions in …

Mass spectrometry imaging of lumpectomy specimens deciphers diacylglycerols as potent biomarkers for the diagnosis of breast cancer

S Mondal, Y Sthanikam, A Kumar, A Nandy… - Analytical …, 2023 - ACS Publications
Detecting breast tumor markers with a fast turnaround time from frozen sections should
foster intraoperative histopathology in breast-conserving surgery, reducing the need for a …

Discovery of lipid profiles in plasma‐derived extracellular vesicles as biomarkers for breast cancer diagnosis

L Liu, M Kawashima, M Sugimoto, K Sonomura… - Cancer …, 2023 - Wiley Online Library
Lipids are a major component of extracellular vesicles; however, their significance in
tumorigenesis and progression has not been well elucidated. As we previously found that …