Enzymatic synthesis of ligand-bearing oligonucleotides for the development of metal-responsive DNA materials

Y Takezawa, M Shionoya - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
Metal-mediated artificial base pairs are some of the most promising building blocks for
constructing DNA-based supramolecules and functional materials. These base pairs are …

Proximity-induced bipedal DNA walker for accurately visualizing microRNA in living cancer cell

X Feng, X Bi, J Feng, S Hu, Y Wang, S Zhao… - Analytical …, 2024 - ACS Publications
DNA walker, a type of dynamic DNA device that is capable of moving progressively along
prescribed walking tracks, has emerged as an ideal and powerful tool for biosensing and …

Metal-dependent activity control of a compact-sized 8–17 DNAzyme based on metal-mediated unnatural base pairing

Y Takezawa, L Hu, T Nakama… - Chemical …, 2024 - pubs.rsc.org
A compact 8–17 DNAzyme was modified with a CuII-meditated artificial base pair to develop
a metal-responsive allosteric DNAzyme. The base sequence was rationally designed based …

Highly integrated, self-powered and activatable bipedal DNA nanowalker for imaging of base excision repair in living cells

R Lai, X Pan, Y Qin, J Liang, L Wu, M Dong… - Journal of …, 2024 - Springer
DNA walkers have attracted considerable attention in biosensing and bioimaging.
Compared with the conventional single leg-based DNA walker, the bipedal DNA walker has …

[HTML][HTML] Molecular Origami: Designing Functional Molecules of the Future

H Ishida, T Ito, A Kuzuya - Molecules, 2025 - mdpi.com
In the field of chemical biology, DNA origami has been actively researched. This technique,
which involves folding DNA strands like origami to assemble them into desired shapes, has …

Ligase-mediated synthesis of Cu II-responsive allosteric DNAzyme with bifacial 5-carboxyuracil nucleobases

Y Takezawa, H Zhang, K Mori, L Hu, M Shionoya - Chemical Science, 2024 - pubs.rsc.org
A CuII-responsive allosteric DNAzyme has been developed by introducing bifacial 5-
carboxyuracil (caU) nucleobases, which form both hydrogen-bonded caU–A and metal …

Allosteric stem-loop multicomponent DNAzyme: A versatile stimuli-responsive switch for nanotweezer operations and multifunctional biosensing

Y Zhang, D Bai, J Pu, L Zhang, W Wang, T Feng… - Chemical Engineering …, 2024 - Elsevier
DNAzyme, possessing the capabilities of both encoding information and catalyzing chemical
reactions, holds significant value in advancing the widespread application of dynamic …

Kinetics of Strand Displacement Reaction with Acyclic Artificial Nucleic Acids

K Makino, I Sugiyama, H Asanuma… - Angewandte Chemie …, 2024 - Wiley Online Library
Toehold‐mediated strand displacement (TMSD) reaction, one of the DNA nanotechnologies,
has great potential as s biological programmable platform in the cellular environment …

Selective Formation of Pd‐DNA Hybrids Using Tailored Palladium‐Mediated Base Pairs: Towards Heteroleptic Pd‐DNA Systems

A Pérez‐Romero, M Cano‐Muñoz… - Angewandte …, 2024 - Wiley Online Library
The formation of highly organized metal‐DNA structures has significant implications in
bioinorganic chemistry, molecular biology and material science due to their unique …

Contiguous Silver (I)-Mediated Base Pairs of Imidazophenanthroline and Canonical Nucleobases in DNA Duplexes: Formation of Classical Duplexes versus …

N Lefringhausen, C Erbacher, M Elinkmann… - Bioconjugate …, 2023 - ACS Publications
Metal-mediated base pairs represent a topical alternative to canonical hydrogen-bonded
base pairs. In this context, the ligand 1 H-imidazo [4, 5-f][1, 10] phenanthroline (P) was …