In Part 2 of this review, a critical examination of the pertinent scientific literature is
undertaken in order to assess the interaction risk that popular dietary supplements may pose …

The excellent therapeutic potential of a variety of phytochemicals in different diseases has
been proven by extensive studies throughout history. However, most phytochemicals are …

Silymarin is an extract from the seeds (fruits) of Silybum marianum that contains
flavonolignans and flavonoids. Although it is frequently used as a hepatoprotective agent, its …

In recent years, due to their distinctive and adaptable therapeutic effects, many natural
bioactive compounds have been commonly used to treat diseases. Their limited solubility …

Abstract Approximately 70–80% of drugs in clinical drug development suffer low aqueous
solubility, poor oral bioavailability, and limited intestinal permeability. Flavonoids are a …

Silymarin is a complex mixture of four flavonolignan isomers (silybin, isosilybin, silydianin
and silychristin) obtained from 'milk thistle'(Silybum marianum). This plant compound is used …

A drug product should have aqueous solubility to avoid bioavailability issues. Low and
erratic bioavailability is a problem encountered by almost 40–60% of new drug products …

Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological entity that is typically
characterized by intrahepatic ectopic steatosis. Nowadays, NAFLD has surpassed viral …

Radiation can produce biological damage, mainly oxidative stress, via production of free
radicals, including reactive oxygen species (ROS). Nanoparticles are of interest as …

Present work demonstrated the influence of novel amphiphilic carrier Soluplus® on the
solubility and oral bioavailability of Morin hydrate (MOR). Spray-dried solid dispersions …