Next-generation sequencing technology: current trends and advancements

H Satam, K Joshi, U Mangrolia, S Waghoo, G Zaidi… - Biology, 2023 - mdpi.com
Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics
research. NGS can sequence millions of DNA fragments at once, providing detailed …

Saffron, its active components, and their association with DNA and histone modification: A narrative review of current knowledge

M Rashid, H Brim, H Ashktorab - Nutrients, 2022 - mdpi.com
Intensive screening for better and safer medications to treat diseases such as cancer and
inflammatory diseases continue, and some phytochemicals have been discovered to have …

S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for …

R Kumar, N Khandelwal, Y Chander, H Nagori… - Antiviral research, 2022 - Elsevier
We report the in vitro antiviral activity of DZNep (3-Deazaneplanocin A; an inhibitor of S-
adenosylmethionine-dependent methyltransferase) against SARS-CoV-2, besides …

Maternal exercise mediates hepatic metabolic programming via activation of AMPK-PGC1α axis in the offspring of obese mothers

P Kasper, S Breuer, T Hoffmann, C Vohlen… - Cells, 2021 - mdpi.com
Maternal obesity is associated with an increased risk of hepatic metabolic dysfunction for
both mother and offspring and targeted interventions to address this growing metabolic …

Impact of maternal cardiometabolic status after bariatric surgery on the association between telomere length and adiposity in offspring

R San-Cristobal, J de Toro-Martín, F Guénard… - Scientific Reports, 2023 - nature.com
The impact of bariatric surgery on metabolic and inflammatory status are reflected in the
epigenetic profile and telomere length mediated by the changes in the metabolic status of …

Oxidative stress responses in obese individuals undergoing bariatric surgery: Impact on carcinogenesis

DA Ribeiro, GN da Silva, IT Malacarne… - …, 2024 - pmc.ncbi.nlm.nih.gov
Obesity is a big public health problem that claims several thousand lives every year.
Bariatric surgery has arisen as a suitable procedure for treating obesity, particularly morbid …

[PDF][PDF] Next-Generation Sequencing Technology: Current Trends and Advancements. Biology 2023, 12, 997

H Satam, K Joshi, U Mangrolia, S Waghoo, G Zaidi… - 2023 - researchgate.net
The advent of next-generation sequencing (NGS) has brought about a paradigm shift in
genomics research, offering unparalleled capabilities for analyzing DNA and RNA …

Epigenetic Alterations as Vital Aspects of Bortezomib Molecular Action

P Kulig, K Łuczkowska, E Bakinowska, B Baumert… - Cancers, 2023 - mdpi.com
Simple Summary The implantation of proteasome inhibitors was a milestone in the treatment
of multiple myeloma (MM). One such first-in-class molecule was bortezomib (BTZ). Its …

[HTML][HTML] Harnessing Epigenetic Mechanisms to Overcome Immune Evasion in Cancer: The Current Strategies and Future Directions

R Panda, S Mohan, C Vellapandian - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Combining epigenetic alterations with cancer immunotherapy offers a promising approach
to improve therapeutic outcomes by targeting the complex biology of tumors. Epigenetic …

Molecular remodeling of adipose tissue is associated with metabolic recovery after weight loss surgery

A Bouchard-Mercier, J de Toro-Martín… - Journal of Translational …, 2022 - Springer
Background Bariatric surgery is an effective therapy for individuals with severe obesity to
achieve sustainable weight loss and to reduce comorbidities. Examining the molecular …