Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …

Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via
cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3 …

Rheumatoid arthritis (RA) causes a huge medical burden due to its high morbidity and
disability rate. Emerging evidences demonstrate that RA has a tumor-like microenvironment …

Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of
molecular biomarkers and mediators of intercellular communication. While most …

Background The promise of precision cancer medicine presently centers around the
genomic sequence of a patient's tumor being translated into timely, actionable information to …

Cell-free DNA (cfDNA) is easily accessible in peripheral blood and can be used as
biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA …

Disclosures: P. Izmirly reported personal fees from GlaxoSmithKline outside the submitted
work. JP Buyon reported personal fees from Bristol-Myers Squibb LN advisory board …

Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an
important element that propels the pathological progression of a plethora of diseases. DNA …

Emerging evidence supports that mitochondrial dysfunction contributes to systemic lupus
erythematosus (SLE) pathogenesis. Here we show that programmed mitochondrial removal …