Mitochondrial dysfunction after repeated mild blast traumatic brain injury is attenuated by a mild mitochondrial uncoupling prodrug

WB Hubbard, HJ Vekaria, GV Velmurugan… - Journal of …, 2023 - liebertpub.com
Mild traumatic brain injury (mTBI) results in impairment of brain metabolism, which is
propagated by mitochondrial dysfunction in the brain. Mitochondrial dysfunction has been …

Metabotropic glutamate receptor 2 expression is chronically elevated in male rats with post-traumatic stress disorder related behavioral traits following repetitive low …

R De Gasperi, MA Gama Sosa… - Journal of …, 2024 - liebertpub.com
Many military veterans who experienced blast-related traumatic brain injuries in the conflicts
in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems …

Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging

MO Kilgore, WB Hubbard - International Journal of Molecular Sciences, 2024 - mdpi.com
Low-level blast (LLB) exposure can lead to alterations in neurological health, cerebral
vasculature, and cerebral blood flow (CBF). The development of cognitive issues and …

Acute gastrointestinal permeability after traumatic brain injury in mice precedes a bloom in Akkermansia muciniphila supported by intestinal hypoxia

AJ DeSana, S Estus, TA Barrett, KE Saatman - Scientific Reports, 2024 - nature.com
Traumatic brain injury (TBI) increases gastrointestinal morbidity and associated mortality.
Clinical and preclinical studies implicate gut dysbiosis as a consequence of TBI and an …

A Self‐Gelling Powder Directly Co‐Assembled by Natural Small Molecules for Traumatic Brain Injury

S Yang, W Luo, X Song, Q Chen, J Liu… - Advanced Functional …, 2024 - Wiley Online Library
The prognosis for traumatic brain injury (TBI) depends largely on prompt hemostasis and
effective pharmacologic interventions. Natural all‐small‐molecule self‐gelling powder …

Anxiety-like Characteristics, Forepaw Thermal Sensitivity Changes and Glial Alterations 1 Month After Repetitive Blast Traumatic Brain Injury in Male Rats

S Kallakuri, N Sadik, CJ Davidson… - Annals of …, 2024 - journals.sagepub.com
Background Many military service members are victims of repetitive blast traumatic brain
injuries (rbTBI) and endure diverse altered psychological and behavioural conditions during …

[HTML][HTML] Circulating Brain-Reactive Autoantibody Profiles in Military Breachers Exposed to Repetitive Occupational Blast

SG Rhind, MY Shiu, O Vartanian, C Tenn… - International Journal of …, 2024 - mdpi.com
Military breachers are routinely exposed to repetitive low-level blast overpressure, placing
them at elevated risk for long-term neurological sequelae. Mounting evidence suggests that …

[HTML][HTML] Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury

J Karam, N Ashfaq, C Benitez, V Morales… - Brain, Behavior, and …, 2025 - Elsevier
Traumatic brain injuries (TBI) are the seventh leading cause of disability globally with 48.99
million prevalent cases and 7.08 million years lived with diability. Approximately 80% of TBI …

Global clock coordination by the SCN through relay and amplification of diffusible and neural signaling

R Silver, Y Yao, J Myung - 2025 - authorea.com
The brain clock, located in the suprachiasmatic nucleus (SCN) of the hypothalamus receives
direct retinal input providing the entire body with an internal representation of external solar …

[PDF][PDF] Effects of Traumatic Brain Injury on the Intestinal Tract and Gut Microbiome

A DeSana - 2023 - uknowledge.uky.edu
Traumatic brain injury (TBI) initiates not only complex neurovascular and glial changes
within the brain but also pathophysiological responses that extend beyond the central …