α7-and α9-containing nicotinic acetylcholine receptors in the functioning of immune system and in pain
I Shelukhina, A Siniavin, I Kasheverov… - International Journal of …, 2023 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the
nervous and immune systems, muscles and on the cells of other organs. In the immune …
nervous and immune systems, muscles and on the cells of other organs. In the immune …
STAT3 as a therapeutic target in the metformin-related treatment
W Zhang, D Li, B Li, X Chu, B Kong - International Immunopharmacology, 2023 - Elsevier
Signal transducers and activators of transcription 3 (STAT3) signaling plays an important
role in mediating tumor progression, inflammation, cardiovascular disease, and other …
role in mediating tumor progression, inflammation, cardiovascular disease, and other …
LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription
B Xiu, Y Chi, L Liu, W Chi, Q Zhang, J Chen, R Guo… - Molecular cancer, 2019 - Springer
Background The majority of breast cancer patients die of metastasis rather than primary
tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly …
tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly …
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle …
LA Aqrawi, HK Galtung, EM Guerreiro… - Arthritis research & …, 2019 - Springer
Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and
La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of …
La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of …
SLURP-1 controls growth and migration of lung adenocarcinoma cells, forming a complex with α7-nAChR and PDGFR/EGFR heterodimer
ML Bychkov, MA Shulepko, OV Shlepova… - Frontiers in Cell and …, 2021 - frontiersin.org
Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that
negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR) …
negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR) …
The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers
Alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the main subtypes of nAChRs
that modulates various cancer-related properties including proliferative, anti-apoptotic, pro …
that modulates various cancer-related properties including proliferative, anti-apoptotic, pro …
Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of …
OV Shlepova, MA Shulepko, VO Shipunova… - Frontiers in Cell and …, 2023 - frontiersin.org
α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of
solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative …
solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative …
Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors
M Bychkov, Z Shenkarev, M Shulepko, O Shlepova… - PLoS …, 2019 - journals.plos.org
Lynx1 is the first three-finger prototoxin found in the mammalian central nervous system. It is
a GPI-anchored protein modulating nicotinic acetylcholine receptors (nAChRs) in the brain …
a GPI-anchored protein modulating nicotinic acetylcholine receptors (nAChRs) in the brain …
Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells
MA Shulepko, ML Bychkov, OV Shlepova… - International …, 2020 - Elsevier
Abstract Human Ly-6/uPAR-related protein-1 (SLURP-1) is an allosteric negative modulator
of the α7-type nicotinic acetylcholine receptor (α7-nAChR), one of the key receptors …
of the α7-type nicotinic acetylcholine receptor (α7-nAChR), one of the key receptors …
Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma
M Roos-Mattila, P Kallio, TJ Luck, M Polso… - Communications …, 2024 - nature.com
Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases
(PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high …
(PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high …